The role of galectins in immunity and infection

FT Liu, SR Stowell - Nature Reviews Immunology, 2023 - nature.com
The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by
a wide variety of cells and bind to galactose-containing glycans. Galectins can be located in …

SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals

SA Chen, E Arutyunova, J Lu, MB Khan… - ACS Central …, 2023 - ACS Publications
The main protease of SARS-CoV-2 (Mpro) is the most promising drug target against
coronaviruses due to its essential role in virus replication. With newly emerging variants …

Autophagy and SARS-CoV-2-old players in new games

T Ivanova, Y Mariienko, N Mehterov… - International Journal of …, 2023 - mdpi.com
At present it is well-defined that autophagy is a fundamental process essential for cell life but
its pro-viral and anti-viral role has been stated out with the COVID pandemic. However …

Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles

S Shahbaz, N Bozorgmehr, J Lu, M Osman… - Microbiology …, 2023 - Am Soc Microbiol
There is an urgent need to better understand the impact of different severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants on immune response and disease …

Galectin-9 promotes natural killer cells activity via interaction with CD44

A Rahmati, S Bigam, S Elahi - Frontiers in Immunology, 2023 - frontiersin.org
Natural killer (NK) cells are a potent innate source of cytokines and cytoplasmic granules.
Their effector functions are tightly synchronized by the balance between the stimulatory and …

Depletion of polyfunctional CD26highCD8+ T cells repertoire in chronic lymphocytic leukemia

N Bozorgmehr, M Hnatiuk, AC Peters… - … Hematology & Oncology, 2023 - Springer
Background CD8+ T cells play an essential role against tumors but the role of human CD8+
CD26+ T cell subset against tumors, in particular, haematological cancers such as chronic …

Immunological responses in SARS-CoV-2 and HIV co-infection versus SARS-CoV-2 mono-infection: case report of the interplay between SARS-CoV-2 and HIV

S Shahbaz, W Sligl, M Osman, S Elahi - Allergy, Asthma & Clinical …, 2023 - Springer
Background There is an urgent need to understand the interplay between SARS-CoV-2 and
HIV to inform risk-mitigation approaches for HIV-infected individuals. Objectives We …

[HTML][HTML] Galectins detection for the diagnosis of chronic diseases: an emerging biosensor approach

D Capasso, L Pirone, S Di Gaetano, R Russo… - TrAC Trends in …, 2023 - Elsevier
Galectins are an ancient family of lectins characterized by the specific binding of β-
galactosides through evolutionarily conserved sequence elements of the carbohydrate …

Galectins can serve as biomarkers in COVID-19: A comprehensive systematic review and meta-analysis

AH Behnoush, A Khalaji, SY Alemohammad… - Frontiers in …, 2023 - frontiersin.org
Background Galectins are an eleven-member class of lectins in humans that function as
immune response mediators and aberrancies in their expression are commonly associated …

Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells

L Du, MS Bouzidi, A Gala, F Deiter… - Journal of Molecular …, 2023 - academic.oup.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused
a global economic and health crisis. Recently, plasma levels of galectin-9 (Gal-9), a β …