Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich …

The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD)
are not well understood. Using a large neuroimaging dataset, we identified three latent …

Model-based data analysis of whole-brain dynamics links the observed data to model
parameters in a network of neural masses. Recently, studies focused on the role of regional …

The brain is a complex system comprising a myriad of interacting neurons, posing significant
challenges in understanding its structure, function, and dynamics. Network science has …

Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Animal studies suggest that the apolipoprotein E ε4 (APOE ε4) allele is a culprit of early
microglial activation in Alzheimer's disease (AD). Here, we tested the association between …

Abstract Analysis and interpretation of neuroimaging datasets has become a
multidisciplinary endeavor, relying not only on statistical methods, but increasingly on …

In comparison to other species, the human brain exhibits one of the highest energy
demands relative to body metabolism. It remains unclear whether this heightened energy …

Microglia are specialized brain-resident macrophages that arise from primitive macrophages
colonizing the embryonic brain. Microglia contribute to multiple aspects of brain …