The enhancer of zeste homolog 2 (EZH2) is encoded by the Enhancer of zeste 2 polycomb
repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair …

Transcription factors (TFs) are proteins that interact with specific DNA sequences to regulate
gene expression and play crucial roles in all kinds of biological processes. To keep up with …

Epigenetic modifications regulate critical biological processes that play a pivotal role in the
pathogenesis of cancer. Enhancer of Zeste Homolog 2 (EZH2), a subunit of the Polycomb …

Mutations in chromatin modifying genes frequently occur in many kinds of cancer. Most
mechanistic studies focus on their canonical functions, while therapeutic approaches target …

Cancer has become a prominent cause of death, accounting for approximately 10 million
deaths worldwide as per the World Health Organization report 2020. Epigenetics deal with …

Glioblastoma (GBM) is the most lethal primary brain tumor in adults and harbors a
subpopulation of glioma stem cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), a histone …

Colorectal cancer (CRC) develops in part through the deregulation of different signaling
pathways, including activation of the WNT/β-catenin and PI3K/AKT pathways. Additionally …

More research is being conducted on myocardial cell treatments utilizing stem cell lines that
can develop into cardiomyocytes. All of the forms of cardiac illnesses have shown to be quite …

Therapeutic and diagnostic progresses have significantly reduced the mortality rate among
cancer patients during the last decade. However, there is still a high rate of mortality among …

Activating BRAF mutations occurs in 50–60% of malignant melanomas. Although initially
treatable, the development of resistance to BRAF-targeted therapies (BRAFi) is a major …