Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …

We conduct high coverage (> 30×) whole-genome sequencing of 180 individuals from 12
indigenous African populations. We identify millions of unreported variants, many predicted …

Chronic kidney disease (CKD) describes the long-term condition of impaired kidney function
from any cause. CKD is common and associated with a wide array of complications …

Background: Targeting the gut microbiota may become a new therapeutic to prevent and
delay the progression of chronic kidney disease (CKD). Nonetheless, the causal relationship …

Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …

International Journal of Epidemiology, 2023, e66–e79 https://doi. org/10.1093/ije/dyac114
Advance Access Publication Date: 28 May 2022 Cohort Profile comprehensive molecular …

Exposure to stressful life events increases the risk for psychiatric disorders. Mechanistic
insight into the genetic factors moderating the impact of stress can increase our …

Shear stress generated by urinary fluid flow is an important regulator of renal function. Its
dysregulation is observed in various chronic and acute kidney diseases. Previously, we …

Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent
morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 …