In vitro Analytical Techniques as Screening Tools to investigate the Metal chelate‐DNA interactions

N Varghese, JR Jose, PM Krishna, D Philip… - …, 2023 - Wiley Online Library
Deoxyribose nucleic acid (DNA) is found to be the most efficient pharmacological target of
many synthetic molecules which are deemed as potential drugs with clinical applications …

[HTML][HTML] Potent hepatoprotective activity of common rattan (Calamus rotang L.) leaf extract and its molecular mechanism

WS Anwar, FM Abdel-Maksoud, AM Sayed… - … medicine and therapies, 2023 - Springer
Abstract Background Calamus rotang L.(CR) is an Indian shrub. The leaves and other
organs of the plant are traditionally used in India for treatment of various diseases. The in …

[HTML][HTML] Evaluation of Linkers' Influence on Peptide-Based Piezoelectric Biosensors' Sensitivity to Aldehydes in the Gas Phase

T Wasilewski, D Neubauer, M Wojciechowski… - International Journal of …, 2023 - mdpi.com
Recent findings qualified aldehydes as potential biomarkers for disease diagnosis. One of
the possibilities is to use electrochemical biosensors in point-of-care (PoC), but these need …

Virtual screening reveals aprepitant to be a potent inhibitor of neutral sphingomyelinase 2: implications in blockade of exosome release in cancer therapy

M Moloudizargari, S Hekmatirad, S Gharaghani… - Journal of Cancer …, 2023 - Springer
Purpose Exosomes are membrane-derived nano-vesicles upregulated in pathological
conditions like cancer. Therefore, inhibiting their release is a potential strategy for the …

Molecular docking studies and structural&electronic analysis of gefarnate

SÇ Yavuz - Journal of the Indian Chemical Society, 2023 - Elsevier
This study focused on the structural/electronic features of an anti-ulcer agent, gefarnate. The
molecular geometry of the compound was calculated using Gaussian 09 W software and the …

3-Difluormethyl-5-carbomethoxy-2, 4-pyrazole: Molecular mechanism of the formation and molecular docking study

A Barhoumi, N Ourhriss, M Belghiti… - Current Chemistry …, 2023 - growingscience.com
Application of the Molecular Electron Density Theory (MEDT) for the exploration of the [3+ 2]
cycloaddition processes between methyl propynoate 1 and difluoromethyldiazomethane T …

Switching of newly synthesized linker-based derivatives of non-steroidal anti-inflammatory drugs toward anti-inflammatory and anticancer activity

M Kaur, HM Rehman, G Kaur, A Kaur, M Bansal - Bioorganic Chemistry, 2023 - Elsevier
A new series of linker-based derivatives of non-steroidal anti-inflammatory drugs were
designed and synthesized. All the compounds were well characterized with the help of …

Zinc (II) complex of (Z)-4-((4-nitrophenyl) amino) pent-3-en-2-one, a potential antimicrobial agent: Synthesis, characterization, antimicrobial screening, DFT calculation …

I Waziri, OO Wahab, GA Mala, SO Oselusi… - Bulletin of the Chemical …, 2023 - ajol.info
Herein, the synthesis and characterizations of (Z)-4-((4-nitrophenyl) amino) pent-3-en-2-one
(HL) ligand and its Zn (II) complex are reported. The compounds were characterized using …

[HTML][HTML] Rhodospirillum rubrum L-Asparaginase Conjugates with Polyamines of Improved Biocatalytic Properties as a New Promising Drug for the Treatment of …

NV Dobryakova, DD Zhdanov, NN Sokolov… - Applied Sciences, 2023 - mdpi.com
L-asparaginase Rhodospirillum rubrum (RrA) is an enzyme (amidohydrolases; EC 3.5. 1.1)
that catalyzes the L-asparagine hydrolysis reaction to form L-aspartic acid. Due to the …

Synthesis, Antifungal Activity, and Molecular Docking Studies of Some New Di-O-Isopentanoyl Glucopyranosides

P Matin, MM Matin, MR Rahman… - Physical Chemistry …, 2023 - physchemres.org
Extensive research in the past decades indicated that the sugar ester (SE) type
biomolecules bring long-chain fatty acids with sugar moieties into the plant cells, and play …