Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications
A Angeli, CT Supuran - Journal of Enzyme Inhibition and Medicinal …, 2023 - Taylor & Francis
Click chemistry reactions constitute an important and relatively new approach in the
medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms …
medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms …
Umbelliferone and its synthetic derivatives as suitable molecules for the development of agents with biological activities: a review of their pharmacological and …
A Kornicka, Ł Balewski, M Lahutta, J Kokoszka - Pharmaceuticals, 2023 - mdpi.com
Umbelliferone (UMB), known as 7-hydroxycoumarin, hydrangine, or skimmetine, is a
naturally occurring coumarin in the plant kingdom, mainly from the Umbelliferae family that …
naturally occurring coumarin in the plant kingdom, mainly from the Umbelliferae family that …
Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII
AK El-Damasy, HJ Kim, A Nocentini… - Journal of Enzyme …, 2023 - Taylor & Francis
A series of 6-ureido/amidocoumarins (5a–p and 7a–c) has been designed and synthesised
to develop potent and isoform-selective carbonic anhydrase h CA XI and XII inhibitors. All …
to develop potent and isoform-selective carbonic anhydrase h CA XI and XII inhibitors. All …
[PDF][PDF] Determining the 3-substituted Coumarins inhibitory potential against the HslV protease of E. coli.
OBJECTIVE: The growing bacterial resistance towards classical antibiotics demands the
development of novel approaches for the effective treatment of potentially fatal bacterial …
development of novel approaches for the effective treatment of potentially fatal bacterial …
6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography
A Nocentini, A Bonardi, C Bazzicalupi… - Journal of Medicinal …, 2023 - ACS Publications
Benzoxaborole is currently a scaffold of great relevance in medicinal chemistry. In 2016, it
was reported to be a new and valuable chemotype for designing carbonic anhydrase (CA) …
was reported to be a new and valuable chemotype for designing carbonic anhydrase (CA) …
Recent advances in triazole-benzenesulfonamide hybrids and their biological activities
Hybridization is the process of fusion of two or more existing moieties to make a single
molecule. Triazoles and benzenesulfonamides are the useful pharmacological agents …
molecule. Triazoles and benzenesulfonamides are the useful pharmacological agents …
Arylidine extensions of 3-methyl-5-oxo-4, 5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: synthesis, computational simulations and biological evaluation as …
Several pyrazole-benzene sulfonamides were reported as human carbonic anhydrase
inhibitors. In this research work, a design of Arylidine-extented 5-oxo-pyrazole …
inhibitors. In this research work, a design of Arylidine-extented 5-oxo-pyrazole …
Synthesis of coumarin-azole and azole-azole hybrids as potential antimalarial and anticancer agents
AR Ngwenya - 2023 - ujcontent.uj.ac.za
COPYRIGHT AND CITATION CONSIDERATIONS FOR THIS THESIS/ DISSERTATION o
Attribution — You must give appropriate credit, provide Page 1 COPYRIGHT AND CITATION …
Attribution — You must give appropriate credit, provide Page 1 COPYRIGHT AND CITATION …
In search of new antiviral targets: Design and synthesis of new inhibitors of ZIKV Mtase and potential inhibitors of IMPDH
M Gerace - 2023 - usiena-air.unisi.it
Viral infections are a leading cause of death worldwide. In 2016, WHO declared a public
health emergency due to the spread of the Zika virus (ZIKV). In addition, the recent link …
health emergency due to the spread of the Zika virus (ZIKV). In addition, the recent link …