Nasal sprays for treating COVID-19: a scientific note

VP Chavda, KP Baviskar, DA Vaghela, SS Raut… - Pharmacological …, 2023 - Springer
Clinical management of COVID-19 has been a daunting task. Due to the lack of specific
treatment, vaccines have been regarded as the first line of defence. Innate responses and …

[HTML][HTML] Inflammatory biomarkers to predict the prognosis of acute bacterial and viral infections

AH de Nooijer, P Pickkers, MG Netea, M Kox - Journal of Critical Care, 2023 - Elsevier
Mortality in acute infections is mostly associated with sepsis, defined as 'life-threatening
organ dysfunction caused by a dysregulated host response to infection'. It remains …

Optimal timing of nirmatrelvir/ritonavir treatment after COVID-19 symptom onset or diagnosis: target trial emulation

CKH Wong, JJ Lau, ICH Au, KTK Lau, IFN Hung… - Nature …, 2023 - nature.com
Reports of symptomatic rebound and/or test re-positivity among COVID-19 patients following
the standard five-day treatment course of nirmatrelvir/ritonavir have sparked debates …

Multidisciplinary recommendations for the management of CAR-T recipients in the post-COVID-19 pandemic era

T Zhang, W Tian, S Wei, X Lu, J An, S He… - … Hematology & Oncology, 2023 - Springer
The outbreak of coronavirus disease 2019 (COVID-19) posed an unprecedented challenge
on public health systems. Despite the measures put in place to contain it, COVID-19 is likely …

Immune correlates of protection for SARS-CoV-2, Ebola and Nipah virus infection

B Escudero-Pérez, P Lawrence… - Frontiers in …, 2023 - frontiersin.org
Correlates of protection (CoP) are biological parameters that predict a certain level of
protection against an infectious disease. Well-established correlates of protection facilitate …

Fewer COVID‐19 neurological complications with dexamethasone and remdesivir

A Grundmann, CH Wu, M Hardwick… - Annals of …, 2023 - Wiley Online Library
Objective The objective of this study was to assess the impact of treatment with
dexamethasone, remdesivir or both on neurological complications in acute coronavirus …

Robust humoral and cellular recall responses to AZD1222 attenuate breakthrough SARS-CoV-2 infection compared to unvaccinated

J Maaske, S Sproule, AR Falsey… - Frontiers in …, 2023 - frontiersin.org
Background Breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection in coronavirus disease 2019 (COVID-19) vaccinees typically produces milder …

Unraveling the molecular and cellular pathogenesis of COVID-19-associated liver injury

H Akkiz - Viruses, 2023 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus (SARS-CoV-2) continues to cause substantial morbidity and mortality …

Dynamical modelling of viral infection and cooperative immune protection in COVID-19 patients

Z Zhou, D Li, Z Zhao, S Shi, J Wu, J Li… - PLOS Computational …, 2023 - journals.plos.org
Once challenged by the SARS-CoV-2 virus, the human host immune system triggers a
dynamic process against infection. We constructed a mathematical model to describe host …

Multiple cohort study of hospitalized SARS-CoV-2 in-host infection dynamics: Parameter estimates, identifiability, sensitivity and the eclipse phase profile

CS Korosec, MI Betti, DW Dick, HK Ooi… - Journal of Theoretical …, 2023 - Elsevier
Abstract Within-host SARS-CoV-2 modelling studies have been published throughout the
COVID-19 pandemic. These studies contain highly variable numbers of individuals and …