Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

Frailty is a common geriatric syndrome characterized by increased vulnerability and is
associated with adverse clinical events such as falls, hospitalization, and death. Early …

Introduction Ageing is associated with several physiological changes, including changes in
the immune system. Age-related changes in the innate and adaptive immune system are …

Background Neutrophils and lymphocytes represent the larger percentage of all white blood
cells, they vary with age, with a progressive increase of the ratio in the first years of life, and …

Background numerous studies point towards a critical role of Interleukin 6 (IL-6) pathway in
frailty pathogenesis yet the causal relationship between the two remains elusive. Methods …

Background Accurately identifying risk factors that predict fatality in dengue is crucial for
patient triage and clinical management. Our objective was to identify predictors of death …

Objectives To assess the variation of vaccine effectiveness against SARS-CoV-2 infection
during the Delta wave according to frailty status among US veterans. Design Test-negative …

Background Knowledge opportunities lie ahead as everyday activities, social participation,
and psychological resilience might be important predictors for frailty state transitioning in the …

Inflammaging is a low-grade inflammatory state that can be considered an adaptive process
aimed at stimulating appropriate anti-inflammatory response. Frailty is determined by the …

Background Patients with end-stage kidney disease who are undergoing dialysis have
reduced immune responses to COVID-19 vaccination. Frailty is extremely common among …