T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

Interfering with interferons: A critical mechanism for critical COVID-19 pneumonia

HC Su, H Jing, Y Zhang… - Annual Review of …, 2023 - annualreviews.org
Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …

[HTML][HTML] A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection

DG Augusto, LD Murdolo, DSM Chatzileontiadou… - Nature, 2023 - nature.com
Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2
remain asymptomatic,,–. Although most global efforts have focused on severe illness in …

[HTML][HTML] GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

E Pairo-Castineira, K Rawlik, AD Bretherick, T Qi, Y Wu… - Nature, 2023 - nature.com
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype
that we have previously shown to be highly efficient for discovery of genetic associations …

Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint …

M Gyöngyösi, P Alcaide, FW Asselbergs… - Cardiovascular …, 2023 - academic.oup.com
Long COVID has become a world-wide, non-communicable epidemic, caused by long-
lasting multiorgan symptoms that endure for weeks or months after SARS-CoV-2 infection …

[HTML][HTML] Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments

A Gupta, A Konnova, M Smet, M Berkell… - The Journal of …, 2023 - Am Soc Clin Investig
Background The role of host immunity in emergence of evasive SARS-CoV-2 Spike
mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored …

Interferon‐induced transmembrane protein 3 (IFITM3) limits lethality of SARS‐CoV‐2 in mice

AD Kenney, A Zani, J Kawahara, AC Eddy, XL Wang… - EMBO …, 2023 - embopress.org
Interferon‐induced transmembrane protein 3 (IFITM3) is an antiviral protein that alters cell
membranes to block fusion of viruses. Conflicting reports identified opposing effects of …

Human genomics of COVID-19 pneumonia: Contributions of rare and common variants

A Cobat, Q Zhang… - Annual review of …, 2023 - annualreviews.org
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is silent or benign
in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of …

[HTML][HTML] ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway

F Chen, Y Chen, Q Ke, Y Wang, Z Gong… - Journal of Translational …, 2023 - Springer
Background Recent numerous epidemiology and clinical association studies reported that
ApoE polymorphism might be associated with the risk and severity of coronavirus disease …

[HTML][HTML] Post-COVID Syndrome in Adults—An Overview

RE Scharf, JM Anaya - Viruses, 2023 - mdpi.com
This article provides an overview of various aspects related to post-COVID syndrome. Apart
from its prevalence, symptoms and sequelae, risk determinants, and psychosocial …