All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a
therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its …

In Saccharomyces cerevisiae, cryptic transcription at the coding region is prevented by the
activity of Sin3 histone deacetylase (HDAC) complex Rpd3S, which is carried by the …

Transcriptional regulation is commonly governed by alternative promoters. However, the
regulatory architecture in alternative and reference promoters, and how they differ, remains …

Mammalian aging is characterized by the progressive loss of tissue function and increased
risk for disease. Accumulation of senescent cells in aging tissues partly contributes to this …

Epigenetic inheritance during DNA replication requires an orchestrated assembly of
nucleosomes from parental and newly synthesized histones. We analyzed Drosophila HisC …

Aging-related diseases are closely associated with the state of inflammation, which is known
as “inflammaging.” Senescent cells are metabolically active, as exemplified by the secretion …

Loss of transcription-coupled histone H3 lysine 36 trimethylation (H3K36me3) contributes to
shorter lifespans in eukaryotes. However, the molecular mechanism of the decline of …