Matrescence: lifetime impact of motherhood on cognition and the brain

ER Orchard, HJV Rutherford, AJ Holmes… - Trends in cognitive …, 2023 - cell.com
Profound environmental, hormonal, and neurobiological changes mark the transition to
motherhood as a major biosocial life event. Despite the ubiquity of motherhood, the …

Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease

C Barth, A Crestol, AMG de Lange… - The Lancet Diabetes & …, 2023 - thelancet.com
Despite widespread sex differences in prevalence and presentation of numerous illnesses
affecting the human brain, there has been little focus on the effect of endocrine ageing. Most …

Brain-age prediction: A systematic comparison of machine learning workflows

S More, G Antonopoulos, F Hoffstaedter, J Caspers… - NeuroImage, 2023 - Elsevier
The difference between age predicted using anatomical brain scans and chronological age,
ie, the brain-age delta, provides a proxy for atypical aging. Various data representations and …

Beyond sex differences: short-and long-term effects of pregnancy on the brain

TA Puri, JE Richard, LAM Galea - Trends in Neurosciences, 2023 - cell.com
Growing attention has been directed to the inclusion of females in neuroscience studies, and
to the importance of studying sex as a biological variable. However, how female-specific …

First-time fathers show longitudinal gray matter cortical volume reductions: evidence from two international samples

M Martínez-García, M Paternina-Die… - Cerebral …, 2023 - academic.oup.com
Emerging evidence points to the transition to parenthood as a critical window for adult
neural plasticity. Studying fathers offers a unique opportunity to explore how parenting …

Cellular and molecular signatures of motherhood in the adult and ageing rat brain

P Duarte-Guterman, JE Richard… - Open …, 2023 - royalsocietypublishing.org
Pregnancy is marked by robust changes, including brain changes to volume, structure,
connectivity and neuroplasticity. Although some brain changes are restricted to pregnancy …

Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's Disease and …

I Cumplido-Mayoral, M García-Prat, G Operto, C Falcon… - Elife, 2023 - elifesciences.org
Brain-age can be inferred from structural neuroimaging and compared to chronological age
(brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in …

Brain‐wide associations between white matter and age highlight the role of fornix microstructure in brain ageing

M Korbmacher, AM de Lange… - Human brain …, 2023 - Wiley Online Library
Unveiling the details of white matter (WM) maturation throughout ageing is a fundamental
question for understanding the ageing brain. In an extensive comparison of brain age …

The maternal brain is more flexible and responsive at rest: effective connectivity of the parental caregiving network in postpartum mothers

ER Orchard, K Voigt, S Chopra, T Thapa, PGD Ward… - Scientific reports, 2023 - nature.com
The field of neuroscience has largely overlooked the impact of motherhood on brain function
outside the context of responses to infant stimuli. Here, we apply spectral dynamic causal …

Changes in left hippocampal volume in first‐time fathers: Associations with oxytocin, testosterone, and adaptation to parenthood

D Saxbe, M Martínez‐Garcia… - Journal of …, 2023 - Wiley Online Library
The parenting brain may undergo remodeling that supports the adjustment to new
parenthood. Prior work on human mothers has found gray matter volume decreases from …