The destructive effects of coronavirus disease 2019 (COVID-19) on the elderly and people
with cardiovascular disease have been proven. New findings shed light on the role of aging …

This review sought to assess the efficacy, effectiveness and safety of high‐dose inactivated
influenza vaccines (HD‐IIV) for the prevention of laboratory‐confirmed influenza in …

In the field of immunology, a systems biology approach is crucial to understanding the
immune response to infection and vaccination considering the complex interplay between …

An aging-related immune phenotype (ARIP) has been defined as a decrease in naïve T cells
(TN) relative to the accumulation of memory T cells (TM). Recent research implicates ARIP …

In the aging population, the longitudinal decrease in the secretion of steroidal and
polypeptides growth hormones is directly associated with accumulation of senescent cells in …

Context Social determinants of health are drivers of vaccine inequity and lead to higher risks
of complications from infectious diseases in under vaccinated communities. In many …

Aging has a significant impact on the function and metabolism of T cells. Cholesterol, the
most important sterol in mammals, is known as the “gold of the body” because it maintains …

The presentation of an infectious disease in an older adult, especially in a frail older adult or
in the oldest old (≥ 80 years), may differ from other adults. In addition to differences in …

Provided herein are recombinant polypeptides comprising a SARS-CoV-2 S1 protein
binding domain polypeptide and a GM-CSF polypeptide, polynucleotide sequences …