Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Dysregulation of histone lysine methyltransferases and demethylases is one of the major
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …

Summary N 6-methyladenosine (m 6 A) of mRNAs modulated by the METTL3-METTL14-
WTAP-RBM15 methyltransferase complex and m 6 A demethylases such as FTO play …

In vitro, ACE2 translocates to the nucleus to induce SARS-CoV-2 replication. Here, using
digital spatial profiling of lung tissues from SARS-CoV-2-infected golden Syrian hamsters …

Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an
epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely …

In recent decades, the development of targeted drugs has featured prominently in the
treatment of cancer, which is among the major causes of mortality globally. Triazole-fused …

Spinobulbar muscular atrophy (SBMA) is caused by CAG expansions in the androgen
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Chemotherapy, targeted therapy, and immunotherapy are effective against most tumors, but
drug resistance remains a barrier to successful treatment. Lysine-specific demethylase 1 …