Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Disruption of the epigenetic program of gene expression is a hallmark of cancer that initiates
and propagates tumorigenesis. Altered DNA methylation, histone modifications and ncRNAs …

p300 acts as a transcription coactivator and an acetyltransferase that plays an important role
in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is …

In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR)
antagonists is limited mainly due to AR-variants expression and restored AR signaling. The …

The field of genetics has expanded a lot in the past few decades due to the accessibility of
human genome sequences, but still, the regulation of transcription cannot be explicated …

Panobinostat, also known as Farydak®, LBH589, PNB, or panobinostat lactate, is a
hydroxamic acid that has been approved by the Food and Drug Administration (FDA) for its …

Epidemiological data highlight prostate cancer as a significant global health issue, with high
incidence and substantial impact on patients' quality of life. The prevalence of this disease is …

Histones undergo a plethora of post-translational modifications (PTMs) that regulate
nucleosome and chromatin dynamics and thus dictate cell fate. Several evidences suggest …

In the Neurospora circadian system, the White Collar Complex (WCC) drives expression of
the principal circadian negative arm component frequency (frq). FRQ interacts with FRH …