With recent rapid progress in research on aging, there is increasing evidence that many
features commonly considered to be mechanisms or drivers of aging in fact represent …

Cellular senescence has emerged as a fundamental biological mechanism underpinning
the ageing process and has been implicated in the pathogenesis of an increasing number of …

Mammalian aging is characterized by the progressive loss of tissue function and increased
risk for disease. Accumulation of senescent cells in aging tissues partly contributes to this …

Prunella vulgaris L.(P. vulgaris) has long been considered to have antipyretic, analgesic and
anti-inflammatory effects, lowering blood lipids and pressure. Many studies show that in …

Plasticity of tumor cells (multitude of molecular regulation pathways) allows them to evade
cytocidal effects of chemo-and/or radiation therapy. Metabolic adaptation of the surviving …

Epigenetic alterations are a key hallmark of aging but have been limitedly explored in
tissues. Here, using naturally aged murine liver as a model and extending to other quiescent …

With an aging population and the numerous health impacts associated with old age, the
identification of anti-aging drugs has become an important new research direction. Although …

Ten-eleven translocation (TET) enzymes catalyze the oxidation of 5-methylcytosine (5mC),
first to 5-hydroxymethylcytosine (5hmC), then to 5-formylcytosine (5fC), and finally to 5 …

Cellular senescence, a hallmark of aging, is defined as a state of stress-induced proliferative
arrest while maintaining viability and metabolic activity [1, 2]. Senescence was first …

The transcriptional co‐activator with PDZ‐binding motif (TAZ) is a significant transcription
factor downstream of the Hippo pathway regulating organ size, tissue regeneration, cell …