Host organisms utilise a range of genetically encoded cell death programmes in response to
pathogen challenge. Host cell death can restrict pathogen proliferation by depleting their …

Lipopolysaccharide (LPS), also referred to as endotoxin, is the major component of Gram-
negative bacteria's outer cell wall. It is one of the main types of pathogen-associated …

The gamma-interferon (IFNγ)-inducible guanylate-binding proteins (GBPs) promote host
defense against gram-negative cytosolic bacteria in part through the induction of an …

Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is
the major constituent of the outer membrane of gram-negative bacteria. Endothelial cells …

Alzheimer's disease (AD), the most common type of dementia, is a neurodegenerative
disorder characterized by progressive cognitive dysfunction. Epidemiological investigation …

The immune system of multicellular organisms protects them from harmful microbes. To
establish an infection in the face of host immune responses, pathogens must evolve specific …

Pyroptosis is an inflammatory form of cell death induced upon recognition of invading
microbes. During an infection, pyroptosis is enhanced in interferon-gamma-exposed cells …

Inflammasomes are a group of protein complex located in cytoplasm and assemble in
response to a wide variety of pathogen‐associated molecule patterns, damage‐associated …

Pathogenic microbes invade the human body and trigger a host immune response to defend
against the infection. In response, host-adapted pathogens employ numerous virulence …

Abstract Familial Mediterranean Fever (FMF) is the most common monogenic
autoinflammatory disorder. FMF is caused by mutations in the MEFV gene, encoding pyrin …