A major immunopathological feature of Coronavirus disease-2019 (COVID-19) is excessive
inflammation in the form of “cytokine storm”. The storm is characterized by injurious levels of …

Introduction Chimeric antigen receptor (CAR) T-cell is among the most prevalent
approaches that act by directing T-cells toward cancer; however, they need to be optimized …

The IFN system constitutes a powerful antiviral defense machinery. Consequently, effective
IFN responses protect against severe COVID-19 and exogenous IFNs inhibit SARS-CoV-2 …

Interferon (IFN) has been highlighted in several randomized controlled trials as an attractive
therapeutic candidate based plausible mode of action, suppressed response in severe …

Interferons were repeatedly used in the therapy of COVID-19 due to their antiviral effects.
Three recently published randomized controlled clinical phase III trials (WHO SOLIDARITY …

Neuroplasticity or neural plasticity implicates the adaptive potential of the brain in response
to extrinsic and intrinsic stimuli. The concept has been utilized in different contexts such as …

Gait deficits are found in various degenerative central nervous system conditions, and are
particularly a hallmark of Parkinson's disease (PD). While there is no cure for such …

Purpose The neurotropism of SARS-CoV-2 and the consequential damage to the olfactory
system have been proposed as one of the possible underlying causes of olfactory …

The inflammasomes refer to cytosolic multimolecular complexes within the innate immunity
which drive inflammatory feedbacks. Based on structure, inflammasomes are divided into …

Since the outbreak of the SARS-CoV-2 pandemic in 2019, our understanding of the disease
and its pathophysiology has evolved, paving the way to more effective therapeutic and …