[HTML][HTML] Neurostimulation as a putative method for the treatment of drug-resistant epilepsy in patient and animal models of epilepsy
F Bakhtiarzadeh, M Zare, Z Ghasemi… - Basic and Clinical …, 2023 - ncbi.nlm.nih.gov
A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and
social issues as a result of recurring seizures, which is regarded as a chronic brain disease …
social issues as a result of recurring seizures, which is regarded as a chronic brain disease …
Chemogenetic inhibition of subicular seizure-activated neurons alleviates cognitive deficit in male mouse epilepsy model
L Yang, Q Zhang, X Wu, X Qiu, F Fei, N Lai… - Acta Pharmacologica …, 2023 - nature.com
Cognitive deficit is a common comorbidity in temporal lobe epilepsy (TLE) and is not well
controlled by current therapeutics. How epileptic seizure affects cognitive performance …
controlled by current therapeutics. How epileptic seizure affects cognitive performance …
Efficacy of different strategies of responsive neurostimulation on seizure control and their association with acute neurophysiological effects in rats
F Zhang, Y Yang, Y Xin, Y Sun, C Wang, J Zhu… - Epilepsy & Behavior, 2023 - Elsevier
Responsive neurostimulation (RNS) has shown promising but limited efficacy in the
treatment of drug-resistant epilepsy. The clinical utility of RNS is hindered by the incomplete …
treatment of drug-resistant epilepsy. The clinical utility of RNS is hindered by the incomplete …
Alpha adrenergic receptors have role in the inhibitory effect of electrical low frequency stimulation on epileptiform activity in rats
Aim: Low frequency stimulation (LFS) inhibits neuronal hyperexcitability following epileptic
activity. However, knowledge about LFS'inhibitory mechanisms is lacking. Here, α1 and α2 …
activity. However, knowledge about LFS'inhibitory mechanisms is lacking. Here, α1 and α2 …
Biohybrid restoration of the hippocampal loop re-establishes the non-seizing state in an in vitro model of limbic seizures
Objective. The compromise of the hippocampal loop is a hallmark of mesial temporal lobe
epilepsy (MTLE), the most frequent epileptic syndrome in the adult population and the most …
epilepsy (MTLE), the most frequent epileptic syndrome in the adult population and the most …
Subicular circuit in epilepsy: deconstruct heterogeneity for precise therapeutics
Y Wang, M Liu, Q Wang - Frontiers in Neuroscience, 2023 - frontiersin.org
Temporal lobe epilepsy (TLE) is the most common form of epilepsy, accounting for more
than half of adult patients (Kanner and Bicchi, 2022). The dysfunction of the …
than half of adult patients (Kanner and Bicchi, 2022). The dysfunction of the …
Applications of long-term data from neurostimulation devices
P Dugan, VR Rao - Neurostimulation for Epilepsy, 2023 - Elsevier
Three neurostimulation therapies have been approved for use in drug-resistant focal
epilepsies: vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive …
epilepsies: vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive …
Predicting Pharmacoresistance in Drug-Naïve Temporal Lobe Epilepsy Using Ictal EEGs
Z Chen, Y Gong, C Xu, Z Zhang, S Zhang, X Li, X Qiu… - papers.ssrn.com
Background: One-third of patients with epilepsy are resistant to pharmacological
interventions. Early prediction of pharmacoresistance is therapeutically significant to …
interventions. Early prediction of pharmacoresistance is therapeutically significant to …