Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Q Lu, D Kou, S Lou, M Ashrafizadeh, AR Aref… - Journal of Hematology & …, 2024 - Springer
Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

Fcγ receptors and immunomodulatory antibodies in cancer

F Galvez-Cancino, AP Simpson, C Costoya… - Nature Reviews …, 2024 - nature.com
The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and
programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to …

Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with Cd47

C Huang, X Wang, Y Wang, Y Feng, X Wang, S Chen… - Nature Cancer, 2024 - nature.com
Immunosuppressive myeloid cells hinder immunotherapeutic efficacy in tumors, but the
precise mechanisms remain undefined. Here, by performing single-cell RNA sequencing in …

TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells

H Wang, RA Sica, G Kaur, PM Galbo Jr, Z Jing… - Nature …, 2024 - nature.com
Acute myeloid leukemia (AML) is initiated and sustained by a hierarchy of leukemia stem
cells (LSCs), and elimination of this cell population is required for curative therapies. Here …

Anti-CTLA-4 nanobody as a promising approach in cancer immunotherapy

M Babamohamadi, N Mohammadi, E Faryadi… - Cell Death & …, 2024 - nature.com
Cancer is one of the most common diseases and causes of death worldwide. Since common
treatment approaches do not yield acceptable results in many patients, developing …

Cell‐Based Micro/Nano‐Robots for Biomedical Applications: A Review

B Chen, H Sun, J Zhang, J Xu, Z Song, G Zhan, X Bai… - Small, 2024 - Wiley Online Library
Micro/nano‐robots are powerful tools for biomedical applications and are applied in disease
diagnosis, tumor imaging, drug delivery, and targeted therapy. Among the various types of …

CXCR2 inhibition in G-MDSCs enhances CD47 blockade for melanoma tumor cell clearance

A Banuelos, A Zhang, H Berouti… - Proceedings of the …, 2024 - National Acad Sciences
The use of colony-stimulating factor-1 receptor (CSF1R) inhibitors has been widely explored
as a strategy for cancer immunotherapy due to their robust depletion of tumor-associated …

Orchestrating Precision within the Tumor Microenvironment by Biomimetic Nanoprodrugs for Effective Tumor Therapy

Y Wang, H Xu, X Huang, Y Zhang, Y Lu… - … Applied Materials & …, 2024 - ACS Publications
Malignant tumors are still one of the most deadly diseases that threaten human life and
health. However, developing new drugs is challenging due to lengthy trials, funding …

The Hippo-YAP signaling pathway drives CD24-mediated immune evasion in esophageal squamous cell carcinoma via macrophage phagocytosis

X Zhou, Z Yan, J Hou, L Zhang, Z Chen, C Gao… - Oncogene, 2024 - nature.com
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in the
world with poor prognosis. Despite the promising applications of immunotherapy, the …

CD24 blockade promotes anti‐tumor immunity in oral squamous cell carcinoma

KL Zou, Z Lan, H Cui, YY Zhao, WM Wang… - Oral diseases, 2024 - Wiley Online Library
Objectives Our study elucidates the prognostic role of cluster of differentiation (CD) 24
expression in oral squamous cell carcinoma (OSCC) and determines whether targeting …