Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …

Extrachromosomal DNA (ecDNA) has recently been recognized as a major contributor to
cancer pathogenesis that is identified in most cancer types and is associated with poor …

Conclusions: These findings delineate the genome-wide eccDNAs profiling of HCC and
highlight the functional significance of miRNA-containing eccDNAs in tumorigenesis …

In cancer, oncogenes can untether themselves from chromosomes onto circular,
extrachromosomal DNA (ecDNA) particles. ecDNA are common in many of the most …

Long noncoding RNAs (lncRNAs) are a class of RNA molecules exceeding 200 nucleotides
in length that lack long open-reading frames. Transcribed predominantly by RNA …

Higher-order genome structure influences the transcriptional regulation of cellular genes
through the juxtaposition of regulatory elements, such as enhancers, close to promoters of …

Extrachromosomal circular DNAs (eccDNAs) have emerged as important intra-cellular
mobile genetic elements that affect gene copy number and exert in trans regulatory roles …

The clinical implications of extrachromosomal DNA (ecDNA) in cancer therapy remain
largely elusive. Here, we present a comprehensive analysis of ecDNA amplification spectra …

Extrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many
cancers. They are an important means of oncogene amplification, and correlate with …

Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent
amplifications in oncogenes. However, the mechanisms leading to amplicons that involve …