Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

Understanding the processes and mechanisms underlying early human embryo
development has become an increasingly active and important area of research. It has …

Abstract Development requires coordinated interactions between the epiblast, which
generates the embryo proper; the trophectoderm, which generates the placenta; and the …

Somatic cell nuclear transfer (SCNT) successfully clones cynomolgus monkeys, but the
efficiency remains low due to a limited understanding of the reprogramming mechanism …

While studied extensively in model systems, human gastrulation remains obscure. The
scarcity of fetal biological material as well as ethical considerations limit our understanding …

Progress in understanding early human development has been impeded by the scarcity of
reference datasets from natural embryos, particularly those with spatial information during …

Loss of Cdx2 in vivo leads to stunted development of the allantois, an extraembryonic
mesoderm-derived structure critical for nutrient delivery and waste removal in the early …

Mechanisms specifying amniotic ectoderm and surface ectoderm are unresolved in humans
due to their close similarities in expression patterns and signal requirements. This lack of …

In the first days of life, cells of the mammalian embryo segregate into two distinct lineages,
trophectoderm and inner cell mass. Unlike nonmammalian species, mammalian …

Non-human primates (NHPs) are increasingly used in preclinical trials to test the safety and
efficacy of biotechnology therapies. Nonetheless, given the ethical issues and costs …