TYK2: an emerging therapeutic target in rheumatic disease
Abstract Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family of intracellular
signalling molecules. By participating in signalling pathways downstream of type I …
signalling molecules. By participating in signalling pathways downstream of type I …
ECCO guidelines on extraintestinal manifestations in inflammatory bowel disease
This is the second European Crohn's and Colitis Organisation [ECCO] evidence-based
consensus on extraintestinal manifestations [EIMs] of inflammatory bowel disease [IBD] and …
consensus on extraintestinal manifestations [EIMs] of inflammatory bowel disease [IBD] and …
Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity
Immune responses are tightly regulated yet highly variable between individuals. To
investigate human population variation of trained immunity, we immunized healthy …
investigate human population variation of trained immunity, we immunized healthy …
A unified metric of human immune health
R Sparks, N Rachmaninoff, WW Lau, DC Hirsch… - Nature Medicine, 2024 - nature.com
Immunological health has been challenging to characterize but could be defined as the
absence of immune pathology. While shared features of some immune diseases and the …
absence of immune pathology. While shared features of some immune diseases and the …
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms
MR Lincoln, N Connally, PP Axisa, C Gasperi… - Nature Genetics, 2024 - nature.com
Autoimmune and inflammatory diseases are polygenic disorders of the immune system.
Many genomic loci harbor risk alleles for several diseases, but the limited resolution of …
Many genomic loci harbor risk alleles for several diseases, but the limited resolution of …
The association of gluten-free diet with thyroid autoimmunity in patients with celiac disease: a meta-analysis
Y Liu, N Yao, Y Wang, Y Dong, L Wang, F Wang… - Food & function, 2024 - pubs.rsc.org
Background: Thyroid autoimmunity is an immune response to thyroid antigens that causes
varying degrees of thyroid dysfunction. The sole effective treatment for Celiac Disease (CD) …
varying degrees of thyroid dysfunction. The sole effective treatment for Celiac Disease (CD) …
Large-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults
L Yang, YN Ou, BS Wu, WS Liu, YT Deng… - Nature …, 2024 - nature.com
The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs)
remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK …
remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK …
[HTML][HTML] Shared aetiology underlying multiple sclerosis and other immune mediated inflammatory diseases: Swedish familial co-aggregation and large-scale genetic …
Background While multiple sclerosis (MS) affects less than 1% of the general population,
immune mediated inflammatory diseases (IMIDs) collectively influence 5–10% of the …
immune mediated inflammatory diseases (IMIDs) collectively influence 5–10% of the …
GENIUS-MAWII: For robust Mendelian randomization with many weak invalid instruments
Mendelian randomization (MR) addresses causal questions using genetic variants as
instrumental variables. We propose a new MR method, G-Estimation under No Interaction …
instrumental variables. We propose a new MR method, G-Estimation under No Interaction …
Coeliac disease as a model for understanding multiple sclerosis
The genetic architecture of multiple sclerosis (MS) is similar to that of coeliac disease, with
human leukocyte antigen (HLA) being the greatest genetic determinant in both diseases …
human leukocyte antigen (HLA) being the greatest genetic determinant in both diseases …