The field of regenerative medicine has witnessed remarkable advancements with the
emergence of induced pluripotent stem cells (iPSCs) derived from a variety of sources …

Lipid-based complex injectables are renowned for their effectiveness in delivering drugs,
with many approved products. While significant strides have been made in formulating …

The lethality, chemoresistance and metastatic characteristics of cancers are associated with
phenotypically plastic cancer stem cells (CSCs). How the non-cell autonomous signalling …

During brain development, neural progenitors expand through symmetric divisions before
giving rise to differentiating cell types via asymmetric divisions. Transition between those …

Background & Aims The dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) is
linked to the presence of pancreatic cancer stem-like cells (CSCs) that respond poorly to …

The human genome has many short tandem repeats, yet the normal functions of these
repeats are unclear. The 5′ untranslated region (UTR) of the fragile X messenger …

Recent developments in auxin-inducible degron (AID) technology have increased its
popularity for chemogenetic control of proteolysis. However, generation of human AID cell …

Mechanistic toxicology seeks to identify the molecular and cellular mechanisms by which
toxicants exert their deleterious effects. One powerful approach is to generate mutations in …

Parkinson's disease (PD) is a neurodegenerative disorder caused by complex genetic and
environmental factors. Genome-edited human pluripotent stem cells (hPSCs) offer the …

Introduction Arrhythmias are disturbances in the normal rhythm of the heart and account for
significant cardiovascular morbidity and mortality worldwide. Historically, preclinical …