Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies

RS Duncan, SM Riordan, MC Gernon… - Neural Regeneration …, 2024 - journals.lww.com
Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a
variety of effects in the human body. They have been studied in cellular and animal models …

Subjective, behavioral and neurobiological effects of cannabis and cannabinoids in social anxiety

BA Rosário, JA Lemes, MP de Lima… - Reviews in the …, 2024 - degruyter.com
Social anxiety disorder (SAD) is a debilitating disorder, characterized by fear and anxiety in
social situations. Evidence suggests that the levels of SAD are rising, in particularly after the …

Cannabidiol and its potential evidence-based psychiatric benefits–a critical review

I Dammann, C Rohleder, FM Leweke - Pharmacopsychiatry, 2024 - thieme-connect.com
The endocannabinoid system shows promise as a novel target for treating psychiatric
conditions. Cannabidiol (CBD), a naturally occurring cannabinoid, has been investigated in …

Behavioral observations, heart rate and cortisol monitoring in horses following multiple oral administrations of a cannabidiol containing paste (part 2/2)

F Eichler, A Ehrle, M Machnik, KC Jensen… - Frontiers in Veterinary …, 2024 - frontiersin.org
As a remedy against stress and anxiety, cannabidiol (CBD) products are of increasing
interest in veterinary medicine. Limited data is available describing the actual effectiveness …

Increased hippocampal blood flow in people at clinical high risk for psychosis and effects of cannabidiol

C Davies, MG Bossong, D Martins, R Wilson… - Psychological …, 2024 - cambridge.org
BackgroundHippocampal hyperperfusion has been observed in people at Clinical High Risk
for Psychosis (CHR), is associated with adverse longitudinal outcomes and represents a …

Acute effects of different types of cannabis on young adult and adolescent resting-state brain networks

N Ertl, TP Freeman, C Mokrysz, S Ofori… - …, 2024 - nature.com
Adolescence is a time of rapid neurodevelopment and the endocannabinoid system is
particularly prone to change during this time. Cannabis is a commonly used drug with a …

[HTML][HTML] Exploring the safety of cannabidiol (CBD): A comprehensive in vitro evaluation of the genotoxic and mutagenic potential of a CBD isolate and extract from …

A Štern, M Novak, K Kološa, J Trontelj, S Žabkar… - Biomedicine & …, 2024 - Elsevier
Cannabidiol (CBD), a naturally occurring cyclic terpenoid found in Cannabis sativa L., is
renowned for its diverse pharmacological benefits. Marketed as a remedy for various health …

Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic review

T Hurzeler, J Watt, W Logge, E Towers… - Journal of Cannabis …, 2024 - Springer
The underlying neurobiological mechanisms of cannabidiol's (CBD) management of alcohol
use disorder (AUD) remains elusive. Aim We conducted a systematic review of …

Left hemisphere lateralization of the limbic system and frontoparietal network (FPN) correlates with positive and negative symptom improvement following cannabidiol …

ZP Pierce, AS Bogatz, ER Johnson, BE Lear… - Journal of Psychiatric …, 2024 - Elsevier
This voxel-wise meta-analysis assesses current findings about the neural correlates of
cannabidiol on the positive and negative symptoms among individuals with psychosis or …

The anxiolytic effects of cannabinoids: A comprehensive review

K Mallick, MF Khan, S Banerjee - Pharmacology Biochemistry and Behavior, 2024 - Elsevier
Cannabinoids, notably cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), have
emerged as promising candidates for anxiety disorder treatment, supported by both …