Cell type-specific roles of APOE4 in Alzheimer disease
The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases
B De Strooper, E Karran - The EMBO Journal, 2024 - embopress.org
Two phase-III clinical trials with anti-amyloid peptide antibodies have met their primary goal,
ie slowing of Alzheimer's disease (AD) progression. However, antibody therapy may not be …
ie slowing of Alzheimer's disease (AD) progression. However, antibody therapy may not be …
APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease
YT Quiroz, D Aguillon… - … England Journal of …, 2024 - Mass Medical Soc
Background Variants in APOE and PSEN1 (encoding apolipoprotein E and presenilin 1,
respectively) alter the risk of Alzheimer's disease. We previously reported a delay of …
respectively) alter the risk of Alzheimer's disease. We previously reported a delay of …
The advent of Alzheimer treatments will change the trajectory of human aging
DJ Selkoe - Nature Aging, 2024 - nature.com
Slowing neurodegenerative disorders of late life has lagged behind progress on other
chronic diseases. But advances in two areas, biochemical pathology and human genetics …
chronic diseases. But advances in two areas, biochemical pathology and human genetics …
[HTML][HTML] Insights on the use of transgenic mice models in Alzheimer's disease research
MS Pádua, JL Guil-Guerrero, JAM Prates… - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD), the leading cause of dementia, presents a significant global
health challenge with no known cure to date. Central to our understanding of AD …
health challenge with no known cure to date. Central to our understanding of AD …
[HTML][HTML] Neuropathogenesis-on-chips for neurodegenerative diseases
S Amartumur, H Nguyen, T Huynh, TS Kim… - Nature …, 2024 - nature.com
Developing diagnostics and treatments for neurodegenerative diseases (NDs) is
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …
Unraveling the Genetic Landscape of Neurological Disorders: Insights into Pathogenesis, Techniques for Variant Identification, and Therapeutic Approaches
Z Firdaus, X Li - International journal of molecular sciences, 2024 - mdpi.com
Genetic abnormalities play a crucial role in the development of neurodegenerative disorders
(NDDs). Genetic exploration has indeed contributed to unraveling the molecular …
(NDDs). Genetic exploration has indeed contributed to unraveling the molecular …
[HTML][HTML] Parkinson's Disease Dementia Patients: Expression of Glia Maturation Factor in the Brain
Parkinson's disease (PD) is the second most common progressive neurodegenerative
disease characterized by the presence of dopaminergic neuronal loss and motor disorders …
disease characterized by the presence of dopaminergic neuronal loss and motor disorders …
Lessons from genetic studies in Alzheimer disease
G Nicolas - Revue Neurologique, 2024 - Elsevier
Research on Alzheimer disease (AD) genetics has provided critical advances to the
knowledge of AD pathophysiological mechanisms. The etiology of AD can be divided into …
knowledge of AD pathophysiological mechanisms. The etiology of AD can be divided into …
Long-term oral administration of curcumin is effective in preventing short-term memory deterioration and prolonging lifespan in a mouse model of Alzheimer's disease
H Maruyama, T Ooizumi, F Kawakami, TT Lwin… - Advances in Traditional …, 2024 - Springer
Curcumin (Curc) has been shown to have the potential to ameliorate or prevent the
development of Alzheimer's disease (AD). However, most of them are in vitro and in vivo …
development of Alzheimer's disease (AD). However, most of them are in vitro and in vivo …