Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modeling
E Zarate-Sanchez, SC George, ML Moya… - …, 2024 - iopscience.iop.org
The hemorrhagic fever viruses (HFVs) cause severe or fatal infections in humans. Named
after their common symptom hemorrhage, these viruses induce significant vascular …
after their common symptom hemorrhage, these viruses induce significant vascular …
IL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease
N Chen, X Wang, Y Guo, M Zhao, B Cao… - Communications …, 2024 - nature.com
Abstract Tuberous sclerosis complex 2 (TSC2) crucially suppresses Rheb activity to prevent
mTORC1 activation. However, mutations in TSC genes lead to mTORC1 overactivation …
mTORC1 activation. However, mutations in TSC genes lead to mTORC1 overactivation …
MicroRNA-22-3p displaces critical host factors from the 5′ UTR and inhibits the translation of Coxsackievirus B3 RNA
ABSTRACT Coxsackievirus B3 (CVB3) is known to cause acute myocarditis and pancreatitis
in humans. We investigated the microRNAs (miRNAs) that can potentially govern the viral …
in humans. We investigated the microRNAs (miRNAs) that can potentially govern the viral …
Reactive astrocytes promote tumor progression by up-regulating tumor protocadherin 1 expression in lung cancer brain metastasis
M Tang, K Liang, W Duan, S Xia, D Shi, E Li… - Biochemical and …, 2024 - Elsevier
Brain metastasis (BM) is one of the main causes of death in patients with non-small cell lung
carcinoma. The specific pathological processes of BM, which are inextricably linked to the …
carcinoma. The specific pathological processes of BM, which are inextricably linked to the …
[HTML][HTML] Engineering, structure, and immunogenicity of a Crimean–Congo hemorrhagic fever virus pre-fusion heterotrimeric glycoprotein complex
E McFadden, SR Monticelli, A Wang, AR Ramamohan… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Crimean–Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that can cause
severe disease in humans with case fatality rates of 10–40%. Although structures of CCHFV …
severe disease in humans with case fatality rates of 10–40%. Although structures of CCHFV …
Epistasis between N-terminal and receptor-binding domains drives cell entry in a bat coronavirus spike
Understanding the zoonotic risks posed by bat coronaviruses (CoVs) is critical for pandemic
preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) …
preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) …
Bunyavirales
L Jneidi, C Hajal, R Kattan, MY Hindiyeh - Molecular Medical Microbiology, 2024 - Elsevier
The constant evolution of viruses and the emergence and reemergence of viral infections
have exerted tremendous pressure on the public health systems. Indeed, the Bunyavirales …
have exerted tremendous pressure on the public health systems. Indeed, the Bunyavirales …
Production and Purification of Hantavirus Glycoproteins in Drosophila melanogaster S2 Cells
A Meola, P Guardado-Calvo - Recombinant Glycoproteins: Methods and …, 2024 - Springer
Hantaviruses, are rodent-borne viruses found worldwide that are transmitted to humans
through inhalation of contaminated excreta. They can cause a renal or a pulmonary …
through inhalation of contaminated excreta. They can cause a renal or a pulmonary …
A pan-orthohantavirus preclinical human lung xenograft mouse model
M Rissmann, D Noack, T Spliethof, V Vaes, R Stam… - 2024 - researchsquare.com
Orthohantaviruses are emerging zoonotic viruses that can infect humans via the respiratory
tract. There is a clear unmet need for an in vivo model to study orthohantavirus infection in …
tract. There is a clear unmet need for an in vivo model to study orthohantavirus infection in …
[图书][B] Hantaviruses and SARS-CoV-2: cell stress and novel antivirals
W Christ - 2024 - openarchive.ki.se
Hantaviruses and coronaviruses are zoonotic viral pathogens that can cause severe
disease in humans. The global spread of SARS-CoV-2 demonstrated the full pandemic …
disease in humans. The global spread of SARS-CoV-2 demonstrated the full pandemic …