Mendelian randomization as a tool for cardiovascular research: a review
Importance Mendelian randomization (MR) is a statistical approach that has become
increasingly popular in the field of cardiovascular disease research. It offers a way to infer …
increasingly popular in the field of cardiovascular disease research. It offers a way to infer …
Smoking changes adaptive immunity with persistent effects
Individuals differ widely in their immune responses, with age, sex and genetic factors having
major roles in this inherent variability,,,,–. However, the variables that drive such differences …
major roles in this inherent variability,,,,–. However, the variables that drive such differences …
Pathophysiological insights into HFpEF from studies of human cardiac tissue
Heart failure with preserved ejection fraction (HFpEF) is a major, worldwide health-care
problem. Few therapies for HFpEF exist because the pathophysiology of this condition is …
problem. Few therapies for HFpEF exist because the pathophysiology of this condition is …
Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics
Protein glycosylation, a complex and heterogeneous post-translational modification that is
frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a …
frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a …
Blood protein assessment of leading incident diseases and mortality in the UK Biobank
The circulating proteome offers insights into the biological pathways that underlie disease.
Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age …
Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age …
Systemic proteome adaptions to 7-day complete caloric restriction in humans
Surviving long periods without food has shaped human evolution. In ancient and modern
societies, prolonged fasting was/is practiced by billions of people globally for religious …
societies, prolonged fasting was/is practiced by billions of people globally for religious …
Longitudinal plasma proteomics reveals biomarkers of alveolar-capillary barrier disruption in critically ill COVID-19 patients
E Duijvelaar, J Gisby, JE Peters, HJ Bogaard… - Nature …, 2024 - nature.com
The pathobiology of respiratory failure in COVID-19 consists of a complex interplay between
viral cytopathic effects and a dysregulated host immune response. In critically ill patients …
viral cytopathic effects and a dysregulated host immune response. In critically ill patients …
Mapping biological influences on the human plasma proteome beyond the genome
J Carrasco-Zanini, E Wheeler, B Uluvar, N Kerrison… - Nature …, 2024 - nature.com
Broad-capture proteomic platforms now enable simultaneous assessment of thousands of
plasma proteins, but most of these are not actively secreted and their origins are largely …
plasma proteins, but most of these are not actively secreted and their origins are largely …
Single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease
The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the
study of Alzheimer's disease (AD). Integration with complementary multiomics data such as …
study of Alzheimer's disease (AD). Integration with complementary multiomics data such as …
[HTML][HTML] Understanding the genetic complexity of puberty timing across the allele frequency spectrum
Pubertal timing varies considerably and is associated with later health outcomes. We
performed multi-ancestry genetic analyses on~ 800,000 women, identifying 1,080 signals for …
performed multi-ancestry genetic analyses on~ 800,000 women, identifying 1,080 signals for …