G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

Abstract Melatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to
membrane receptors. Several receptor subtypes exist in different species, of which the …

The prostacyclin (PGI2) receptor (IP) is a Gs-coupled receptor associated with blood
pressure regulation, allergy, and inflammatory response. It is a main therapeutic target for …

Adhesion G protein-coupled receptors (aGPCRs) are evolutionarily ancient receptors
involved in a variety of physiological and pathophysiological processes. Modulators of …

The orphan G protein-coupled receptor (GPCR) GPR161 plays a central role in
development by suppressing Hedgehog signaling. The fundamental basis of how GPR161 …

We report a blueprint for the rational design of G protein coupled receptor (GPCR) ligands
with a tailored functional response. The present study discloses the structure-based design …

The adenosine A3 receptor (A3AR), a key member of the G protein-coupled receptor family,
is a promising therapeutic target for inflammatory and cancerous conditions. The selective …

With the diversity of lipid-protein interactions, any observed membrane protein dynamics or
functions directly depend on the lipid bilayer selection. However, the implications of lipid …

Transporters are targeted by endogenous metabolites and exogenous molecules to reach
cellular destinations, but it is generally not understood how different substrate classes …

Physics-based simulation methods can grant atomistic insights into the molecular origin of
the function of biomolecules. However, the potential of such approaches has been hindered …