Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

OBJECTIVES: To identify research priorities in the management, epidemiology, outcome,
and pathophysiology of sepsis and septic shock. DESIGN: Shortly after publication of the …

OBJECTIVES: In this systematic review and meta-analysis we asked: Do predictors of fluid
responsiveness in children perform comparably: 1) in the PICU as in non-PICU settings? 2) …

The volume of oxygen drawn from systemic capillaries down a partial pressure gradient is
determined by the oxygen content of red blood cells (RBCs) and their oxygen-unloading …

Sepsis is a heterogeneous syndrome and phenotypes have been proposed using clinical
data. Less is known about the contribution of protein biomarkers to clinical sepsis …

Though there have been developments in clinical care and management, early and
accurate diagnosis and risk stratification are still bottlenecks in septic shock patients. Since …

Over the past two decades, our understanding of the impact of acute kidney injury, disorders
of fluid balance, and their interplay have increased significantly. In recent years, the …

OBJECTIVES: To determine if a real-time monitoring system with automated clinician alerts
improves 3-hour sepsis bundle adherence. DESIGN: Prospective, pragmatic clinical trial …

Septic shock is a highly lethal and prevalent disease. Progressive circulatory dysfunction
leads to tissue hypoperfusion and hypoxia, eventually evolving to multiorgan dysfunction …

Sepsis-associated kidney injury is common in critically ill patients and significantly increases
morbidity and mortality rates. Several complex pathophysiological factors contribute to its …