Consensus paper: Cerebellum and ageing

A Arleo, M Bareš, JA Bernard, HR Bogoian… - The Cerebellum, 2024 - Springer
Given the key roles of the cerebellum in motor, cognitive, and affective operations and given
the decline of brain functions with aging, cerebellar circuitry is attracting the attention of the …

On epigenetic stochasticity, entropy and cancer risk

AE Teschendorff - … Transactions of the Royal Society B, 2024 - royalsocietypublishing.org
Epigenetic changes are known to accrue in normal cells as a result of ageing and
cumulative exposure to cancer risk factors. Increasing evidence points towards age-related …

Causality-enriched epigenetic age uncouples damage and adaptation

K Ying, H Liu, AE Tarkhov, MC Sadler, AT Lu, M Moqri… - Nature Aging, 2024 - nature.com
Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …

Associations of seven measures of biological age acceleration with frailty and all-cause mortality among adult survivors of childhood cancer in the St. Jude Lifetime …

JL Guida, G Hyun, DW Belsky, GT Armstrong… - Nature Cancer, 2024 - nature.com
Survivors of childhood cancer may experience accelerated biological aging, resulting in
premature frailty and death. We used seven measures of biological age in the St. Jude …

[HTML][HTML] Severe drought exposure in utero associates to children's epigenetic age acceleration in a global climate change hot spot

X Qiao, B Straight, D Ngo, CE Hilton… - Nature …, 2024 - nature.com
The goal of this study is to examine the association between in utero drought exposure and
epigenetic age acceleration (EAA) in a global climate change hot spot. Calculations of EAA …

Clonal hematopoiesis, inflammation, and hematologic malignancy

R Kanagal-Shamanna, DB Beck… - Annual Review of …, 2024 - annualreviews.org
Somatic or acquired mutations are postzygotic genetic variations that can occur within any
tissue. These mutations accumulate during aging and have classically been linked to …

Echocardiographic heart ageing patterns predict cardiovascular and non-cardiovascular events and reflect biological age: the SardiNIA study

A Ganau, M Orrù, M Floris, PS Saba… - European Journal of …, 2024 - academic.oup.com
Aims Age is a crucial risk factor for cardiovascular (CV) and non-CV diseases. As people
age at different rates, the concept of biological age has been introduced as a personalized …

The molecular biology of midgut neuroendocrine neoplasms

AP Webster, C Thirlwell - Endocrine Reviews, 2024 - academic.oup.com
Midgut neuroendocrine neoplasms (NENs) are one of the most common subtypes of NEN,
and their incidence is rising globally. Despite being the most frequently diagnosed …

[HTML][HTML] Sex differences in biological aging and the association with clinical measures in older adults

AZZ Phyo, PD Fransquet, J Wrigglesworth, RL Woods… - Geroscience, 2024 - Springer
Females live longer than males, and there are sex disparities in physical health and disease
incidence. However, sex differences in biological aging have not been consistently reported …

[HTML][HTML] Composite dietary antioxidant index associated with delayed biological aging: a population-based study

H He, X Chen, Y Ding, X Chen, X He - Aging (Albany NY), 2024 - ncbi.nlm.nih.gov
Objective: The objective of this study was to explore the potential correlation between the
composite dietary antioxidant index (CDAI) and biological aging, addressing the insufficient …