The integration of multiomics data with detailed phenotypic insights from electronic health
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …

Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive
ability, is associated with various health and social outcomes. Previous genome-wide …

The advancement of artificial intelligence (AI), algorithm optimization and high-throughput
experiments has enabled scientists to accelerate the discovery of new chemicals and …

Smoking is the most important risk factor for chronic obstructive pulmonary disease (COPD),
however evidence from large-scale studies on whether secondhand smoke (SHS) increases …

Genotype imputation is now fundamental for genome-wide association studies but lacks
fairness due to the underrepresentation of references from non-European ancestries. The …

Objective To evaluate the risk of cognitive impairment among patients with chronic viral
hepatitis. Design A cross-sectional study. Setting Population-based. Participants Individuals …

Background Climate change caused an increase in ambient temperature in the past
decades. Exposure to high ambient temperature could result in biological aging, but relevant …

The underrepresentation of different ancestry groups in large genomic datasets creates
difficulties in interpreting the pathogenicity of monogenic variants. Genetic testing for …

Objectives The purpose of the study is to identify the recessive diseases currently affecting
real‐world pediatric patients in Taiwan, and whether current extended carrier screening …

Background The human leukocyte antigen (HLA) genes, exhibiting significant genetic
diversity, are associated with susceptibility to various clinical diseases and diverse in drug …