Polyploidy (genome duplication) is a pivotal force in evolution. However, the interactions
between parental genomes in a polyploid nucleus, frequently involving subgenome …

Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …

Competition among adult brain cells has not been extensively researched. To investigate
whether healthy glia can outcompete diseased human glia in the adult forebrain, we …

As the only surviving lineages of jawless fishes, hagfishes and lampreys provide a critical
window into early vertebrate evolution1–3. Here, we investigate the complex history, timing …

The emergence of herbicide‐resistant weeds is a significant threat to modern agriculture.
Cross resistance, a phenomenon where resistance to one herbicide confers resistance to …

Inference of cell–cell communication from single-cell RNA sequencing data is a powerful
technique to uncover intercellular communication pathways, yet existing methods perform …

Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …

Gene expression is an essential step in the translation of genotypes into phenotypes.
However, little is known about the transcriptome architecture and the underlying genetic …

Neural–tumor interactions drive glioma growth as evidenced in preclinical models, but
clinical validation is limited. We present an epigenetically defined neural signature of …

Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …