The pursuit for the fountain of youth has long been a fascination amongst scientists and
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …

By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation
(DNAm) predictors of maximum life span (R= 0.89), gestation time (R= 0.96), and age at …

Epigenetic 'clocks' based on DNA methylation have emerged as the most robust and widely
used aging biomarkers, but conventional methods for applying them are expensive and …

To address how conserved DNA methylation-based epigenetic aging is in diverse branches
of the tree of life, we generated DNA methylation data from African clawed frogs (Xenopus …

Motivation Epigenetic clocks are prediction methods based on DNA methylation levels in a
given species or set of species. Defined as multivariate regression models, these DNA …

DNA methylation rates have previously been found to broadly correlate with maximum
lifespan in mammals, yet no precise relationship has been observed. We developed a …

Comparative studies of aging are a promising approach to identifying general properties of
and processes leading to aging. While to date, many comparative studies of aging in …

Phenotypic aging is ubiquitous across mammalian species, suggesting shared underlying
mechanisms of aging. Aging is linked to molecular changes to DNA methylation and gene …

Epigenetic ageing in a human context, has been used to better understand the relationship
between age and factors such as lifestyle and genetics. In an ecological setting, it has been …

Age is a key parameter in population ecology, with a myriad of biological processes
changing with age as organisms develop in early life then later senesce. As age is often …