Single-cell RNA sequencing (scRNA-Seq) is a recent technology that allows for the
measurement of the expression of all genes in each individual cell contained in a sample …

Human fertility is impacted by changes in lifestyle and environmental deterioration. To
increase human fertility, assisted reproductive technology (ART) has been extensively used …

Lipids are indispensable for energy storage, membrane structure and cell signalling.
However, dynamic changes in various categories of endogenous lipids in mammalian early …

Embryonic genome activation (EGA) occurs during preimplantation development and is
characterized by the initiation of de novo transcription from the embryonic genome. Despite …

Non-invasively evaluating gene expression products in human pre-implantation embryos
remains a significant challenge. Here, we develop a non-invasive method for …

Without new transcription, gene expression across the oocyte-to-embryo transition (OET)
relies instead on regulation of mRNA poly (A) tails to control translation. However, how tail …

The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …

Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts
termed blastoids upon switch to inductive medium. However, the underlying mechanisms …

Background Recent developments in single-cell RNA sequencing have opened up a
multitude of possibilities to study tissues at the level of cellular populations. However, the …

Chromatin accessibility remodeling driven by pioneer factors is critical for the development
of early embryos. Current studies have illustrated several pioneer factors as being important …