Kidney disease is a global health crisis affecting more than 850 million people worldwide. In
the United States, annual Medicare expenditures for kidney disease and organ failure …

In vitro and in vivo models play integral roles in preclinical drug research, evaluation, and
precision medicine. In vitro models primarily involve research platforms based on cultured …

Disease modeling with isogenic Induced Pluripotent Stem Cell (iPSC)-differentiated
organoids serves as a powerful technique for studying disease mechanisms. Multiplexed …

During kidney development, nephron epithelia arise de novo from fate-committed
mesenchymal progenitors through a mesenchymal-to-epithelial transition (MET) …

The present study investigated the effect of single as well as a mixture of nanoparticles (ZnO
and CuO NPs) on algae–bacteria consortia using the OECD 96-h toxicity test, one of the first …

A mechanism exploration is an important part of toxicological studies. However, traditional
cell and animal models can no longer meet the current needs for in-depth studies of …

Abstract Wilms tumor‐1 (WT1) is a crucial transcription factor that regulates podocyte
development. However, the epigenomic mechanism underlying the function of WT1 during …

High-throughput drug screening is crucial for advancing healthcare through drug discovery.
However, a significant limitation arises from available in vitro models using conventional 2D …

The scarcity of donor kidneys greatly impacts the survival of patients with end-stage renal
failure. Pigs are increasingly becoming potential organ donors but are limited by …

Human pluripotent stem cell (hPSC)-derived kidney organoids share similarities with the
fetal kidney. However, the current hPSC-derived kidney organoids have some limitations …