The genetic background of inflammatory bowel disease, both Crohn's disease and
ulcerative colitis, has been known for more than 2 decades. In the last 20 years, genome …

Fine-mapping in genome-wide association studies attempts to identify causal SNPs from a
set of candidate SNPs in a local genomic region of interest and is commonly performed in …

Acquisition of immunological memory is an important evolutionary strategy that evolved to
protect the host from repetitive challenges from infectious agents. It was believed for a long …

Abstract Background Barraquer-Simons syndrome (BSS) is a rare, acquired form of
lipodystrophy characterized by progressive loss of upper body subcutaneous fat, which …

Summary Background Coeliac disease (CeD) has been associated with a broad range of
diseases in observational data; however, whether these associations are causal remains …

Abstract Background The duck (Anas platyrhynchos) is one of the principal natural hosts of
influenza A virus (IAV), harbors almost all subtypes of IAVs and resists to many IAVs which …

Lupus nephritis (LN) is the most severe end-organ pathology in Systemic Lupus
Erythematosus (SLE). Research has enhanced our understanding of immune effectors and …

The Human leukocyte antigen (HLA) molecules are central to immune response and have
associations with the phenotypes of various diseases and induced drug toxicity. Further, the …

Abstract The Major Histocompatibility Complex class I (MHC-I) system plays a vital role in
immune responses by presenting antigens to T cells. Allele specific technologies, including …

The imputation of unmeasured genotypes is essential in human genetic research,
particularly in enhancing the power of genome-wide association studies and conducting …