Chromatographic analysis of triple cough therapy; bromhexine, guaiafenesin and salbutamol and pharmaceutical impurity: in-silico toxicity profile of drug impurity

MMZ Sharkawi, MT Safwat, EA Abdelaleem… - BMC chemistry, 2024 - Springer
Abstract Bromhexine (BR), guaiafenesin (GUF) and salbutamol (SAL) are formulated as
Ventocough syrup®(with and without sugar), labeled to contain propyl paraben and sodium …

A Robust HPLC Approach for Quantitation of Camptothecin in Mesoporous Silica Nanoparticles Matrix and in the Presence of Its Degradation Products

R Dave, N Savaliya, A Dobariya… - Journal of AOAC …, 2024 - academic.oup.com
Background Camptothecin is a potent anticancer drug used for the treatment of various
cancers. Objective The goal of this research investigation was to develop and validate a new …

Should the use of acid reducing agents in conjunction with ribociclib be avoided? An integrated QbD approach for assessment of pH-mediated interaction

M Desai, PH Patil, RR Rao, GG Shenoy… - Journal of …, 2024 - academic.oup.com
The objective of the study was to evaluate the possible pH-dependent interaction of
ribociclib succinate with acid-reducing agents, which are concomitantly administered as …

Simultaneous quantification of 4-hydroxytamoxifen and hesperidin in liposomal formulations: Development and validation of a RP-HPLC method

CL Lobo, M Manohar, A Shetty, S Ananya, K Pallavi… - Heliyon, 2024 - cell.com
Breast cancer treatment options are diverse, with tamoxifen commonly used as a selective
estrogen receptor modulator (SERM) for hormone receptor-positive breast cancer. However …

Bioanalytical method development and validation for the quantification of raloxifene hydrochloride from mice plasma by RP-HPLC

AP Johnson, SL Jyothi, PRH Vikram, K Pramod… - Microchemical …, 2024 - Elsevier
Raloxifene hydrochloride (RLX) belongs to the Selective estrogen receptor modulator
(SERM) class of drugs, exhibiting diverse affinity to estrogen receptors. The drug is known …

Determination of resveratrol in nanoformulations using UV-spectroscopy: forced degradation and drug entrapment

B Sonule, N Mehetre, L Kumar - Tenside Surfactants Detergents, 2024 - degruyter.com
Dietary polyphenols from plant sources play an important role in the human diet. They have
various biological effects, such as protein kinase inhibition, antibacterial, anticancer …

Quality by design‐engineered reversed‐phase high‐performance liquid chromatography method development and validation for simultaneous estimation of neomycin …

S Dessai, VS Mannur, R Koli, M Dhond… - Separation Science …, 2024 - Wiley Online Library
The aim of this study was to develop and validate a robust reversed‐phase high‐
performance liquid chromatography (RP‐HPLC) method for the simultaneous estimation of …

Development and validation of stability indicating methods for the simultaneous estimation of antiviral drugs Darunavir and Ritonavir by RP-HPLC in Bulk and Dosage …

R Khambhampati, S Dodda… - Applied …, 2024 - systems.enpress-publisher.com
We have successfully developed and validated a reliable method using reversed phase
high performance liquid chromatography (RP-HPLC) that accurately determines stability …