Integrative multi‐omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention‐Deficit/Hyperactivity Disorder
N Hubers, FA Hagenbeek, R Pool… - American Journal of …, 2024 - Wiley Online Library
The evolving field of multi‐omics combines data and provides methods for simultaneous
analysis across several omics levels. Here, we integrated genomics (transmitted and non …
analysis across several omics levels. Here, we integrated genomics (transmitted and non …
Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at …
Background Osteoarthritis (OA) is a complex, age-related multifactorial degenerative
disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain, and a …
disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain, and a …
Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twins
P Todtenhaupt, TB Kuipers, KL Dijkstra… - Life Science …, 2024 - life-science-alliance.org
The human umbilical cord (hUC) is the lifeline that connects the fetus to the mother.
Hypercoiling of the hUC is associated with pre-and perinatal morbidity and mortality. We …
Hypercoiling of the hUC is associated with pre-and perinatal morbidity and mortality. We …
Twin-based Mendelian Randomization Analyses Highlight Smoking's Effects on Blood DNA Methylation, with Putative Reverse Causation
Epigenome-wide association studies (EWAS) aim to identify differentially methylated loci
associated with complex traits and disorders. EWAS of cigarette smoking shows some of the …
associated with complex traits and disorders. EWAS of cigarette smoking shows some of the …
Intergenerational transmission of complex traits and the offspring methylome
The genetic makeup of parents can directly or indirectly affect their offspring phenome
through genetic transmission or via the environment that is influenced by parental heritable …
through genetic transmission or via the environment that is influenced by parental heritable …
Differential methylation analysis in neuropathologically confirmed dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is a common form of dementia in the elderly population.
We performed genome-wide DNA methylation mapping of cerebellar tissue from …
We performed genome-wide DNA methylation mapping of cerebellar tissue from …
Oleic acid triggers CD4+ T cells to be metabolically rewired and poised to differentiate into proinflammatory T cell subsets upon activation
NA Reilly, F Sonnet, KF Dekkers, JC Kwekkeboom… - bioRxiv, 2024 - biorxiv.org
T cells are the most common immune cells in atherosclerotic plaques and the function of T
cells can be altered by fatty acids. Here, we show that pre-exposure of CD4+ T cells to oleic …
cells can be altered by fatty acids. Here, we show that pre-exposure of CD4+ T cells to oleic …
Exploring Nanopore Direct Sequencing Performance of Forensic Strs, Snps, Indels, and DNA Methylation Markers in a Single Assay
DDSH de Bruin, MA Haagmans… - Snps, Indels, and DNA … - papers.ssrn.com
Introduction: The field of forensic DNA analysis has undergone rapid advancements in
recent decades. The integration of massively parallel sequencing (MPS) has notably …
recent decades. The integration of massively parallel sequencing (MPS) has notably …
Genome-wide DNA methylation in relation to ARID1A deficiency in ovarian clear cell carcinoma
S Li, GJ Meersma, J Kupryjanczyk, S de Jong… - Journal of Translational …, 2024 - Springer
Background The poor chemo-response and high DNA methylation of ovarian clear cell
carcinoma (OCCC) have attracted extensive attentions. Recently, we revealed the …
carcinoma (OCCC) have attracted extensive attentions. Recently, we revealed the …