[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk

Z Wu, J Qu, W Zhang, GH Liu - Molecular Cell, 2024 - cell.com
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Distinguishing between driver and passenger mechanisms of aging

JP de Magalhães - Nature Genetics, 2024 - nature.com
Understanding why we age is a long-standing question, and many mechanistic theories of
aging have been proposed. Owing to limitations in studying the aging process, including a …

[HTML][HTML] The'middle-aging'brain

S Dohm-Hansen, JA English, A Lavelle… - Trends in …, 2024 - cell.com
Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming

A Cipriano, M Moqri, SY Maybury-Lewis… - Nature aging, 2024 - nature.com
Over the past decade, there has been a dramatic increase in efforts to ameliorate aging and
the diseases it causes, with transient expression of nuclear reprogramming factors recently …

Neurotoxic effects of heavy metal pollutants in the environment: Focusing on epigenetic mechanisms

G Yu, L Wu, Q Su, X Ji, J Zhou, S Wu, Y Tang… - Environmental Pollution, 2024 - Elsevier
The pollution of heavy metals (HMs) in the environment is a significant global environmental
issue, characterized by its extensive distribution, severe contamination, and profound …

Gene therapy-mediated partial reprogramming extends lifespan and reverses age-related changes in aged mice

CC Macip, R Hasan, V Hoznek, J Kim, YR Lu… - Cellular …, 2024 - liebertpub.com
Aging is a complex progression of changes best characterized as the chronic dysregulation
of cellular processes leading to deteriorated tissue and organ function. Although aging …

Emerging epigenetic insights into aging mechanisms and interventions

Z Wu, W Zhang, J Qu, GH Liu - Trends in Pharmacological Sciences, 2024 - cell.com
Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Why death and aging? All memories are imperfect

WB Miller Jr, F Baluška, AS Reber… - Progress in Biophysics and …, 2024 - Elsevier
Recent papers have emphasized the primary role of cellular information management in
biological and evolutionary development. In this framework, intelligent cells collectively …

[HTML][HTML] Reversal of biological age in multiple rat organs by young porcine plasma fraction

S Horvath, K Singh, K Raj, SI Khairnar, A Sanghavi… - GeroScience, 2024 - Springer
Young blood plasma is known to confer beneficial effects on various organs in mice and
rats. However, it was not known whether plasma from young adult pigs rejuvenates old rat …

[HTML][HTML] Epigenetic reprogramming as a key to reverse ageing and increase longevity

B Pereira, FP Correia, IA Alves, M Costa… - Ageing research …, 2024 - Elsevier
The pursuit for the fountain of youth has long been a fascination amongst scientists and
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …