An evolutionary perspective on complex neuropsychiatric disease
The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic
architecture of human traits, including the genetic architecture of complex neuropsychiatric …
architecture of human traits, including the genetic architecture of complex neuropsychiatric …
Functional neurogenomics in autism spectrum disorders: A decade of progress
LK Bicks, DH Geschwind - Current Opinion in Neurobiology, 2024 - Elsevier
Advances in autism spectrum disorder (ASD) genetics have identified many genetic causes,
reflecting remarkable progress while at the same time identifying challenges such as …
reflecting remarkable progress while at the same time identifying challenges such as …
Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain
Neuropsychiatric genome-wide association studies (GWASs), including those for autism
spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the …
spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the …
Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice
Whole-brain genome editing to correct single-base mutations and reduce or reverse
behavioral changes in animal models of autism spectrum disorder (ASD) has not yet been …
behavioral changes in animal models of autism spectrum disorder (ASD) has not yet been …
Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms
Background Social affective and communication symptoms are central to autism spectrum
disorder (ASD), yet their severity differs across toddlers: Some toddlers with ASD display …
disorder (ASD), yet their severity differs across toddlers: Some toddlers with ASD display …
Molecular cascades and cell type–specific signatures in ASD revealed by single-cell genomics
Genomic profiling in postmortem brain from autistic individuals has consistently revealed
convergent molecular changes. What drives these changes and how they relate to genetic …
convergent molecular changes. What drives these changes and how they relate to genetic …
Transcriptional cartography integrates multiscale biology of the human cortex
The cerebral cortex underlies many of our unique strengths and vulnerabilities, but efforts to
understand human cortical organization are challenged by reliance on incompatible …
understand human cortical organization are challenged by reliance on incompatible …
The Mef2c gene dose-dependently controls hippocampal neurogenesis and the expression of autism-like behaviors
S Basu, EJ Ro, Z Liu, H Kim, A Bennett… - Journal of …, 2024 - Soc Neuroscience
Mutations in the activity-dependent transcription factor MEF2C have been associated with
several neuropsychiatric disorders. Among these, autism spectrum disorder (ASD)-related …
several neuropsychiatric disorders. Among these, autism spectrum disorder (ASD)-related …
Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms
RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric
disorders; yet, the role of cell type–specific splicing and transcript-isoform diversity during …
disorders; yet, the role of cell type–specific splicing and transcript-isoform diversity during …
Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory
Histone proteins affect gene expression through multiple mechanisms, including through
exchange with histone variants. Recent findings link histone variants to neurological …
exchange with histone variants. Recent findings link histone variants to neurological …