The kidney proximal tubule is a key organ for human metabolism. The kidney responds to
stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate …

Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis
remains elusive, hindering the development of novel therapeutics. In this study, we used …

Urine-derived stem cells (USCs) are a promising source of stem cells for cell therapy, renal
toxicity drug testing, and renal disease biomarker discovery. Patients' own USCs can be …

Cellular senescence represents an irreversible state of cell-cycle arrest during which cells
secrete senescence-associated secretory phenotypes, including inflammatory factors and …

Persistent organic pollutants (POPs), such as polychlorinated diphenyls (PCBs) and
brominated diphenyl ethers (PBDEs), are ubiquitous in the pet cat's living environment and …

Kidney tubules are mostly responsible for pathogenesis of diabetic kidney disease. Actively
reabsorption of iron, high rate of lipid metabolism and exposure to concentrated redox-active …

Transcytosis‐based tubular reabsorption of endogenous proteins is a well‐known energy‐
saving pathway that prevents nutrient loss. However, utilization of this well‐known …

Mitochondria are essential organelles in the human body, serving as the metabolic factory of
the whole organism. When mitochondria are dysfunctional, it can affect all organs of the …

Kidney epithelial cells have very high energy requirements, which are largely met by fatty
acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney …

Background The glucose derivative 3-O-methyl-D-glucose (OMG) is used as a
cryoprotectant in freezing cells. However, its protective role and the related mechanism in …