Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits
Methylation quantitative trait loci (mQTLs) are essential for understanding the role of DNA
methylation changes in genetic predisposition, yet they have not been fully characterized in …
methylation changes in genetic predisposition, yet they have not been fully characterized in …
[HTML][HTML] Genetic control of DNA methylation is largely shared across European and East Asian populations
DNA methylation is an ideal trait to study the extent of the shared genetic control across
ancestries, effectively providing hundreds of thousands of model molecular traits with large …
ancestries, effectively providing hundreds of thousands of model molecular traits with large …
Integrative analysis of genetics, epigenetics and RNA expression data reveal three susceptibility loci for smoking behavior in Chinese Han population
MD Li, Q Liu, X Shi, Y Wang, Z Zhu, Y Guan, J He… - Molecular …, 2024 - nature.com
Despite numerous studies demonstrate that genetics and epigenetics factors play important
roles on smoking behavior, our understanding of their functional relevance and coordinated …
roles on smoking behavior, our understanding of their functional relevance and coordinated …
Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent Causal Cascade on Hypertension
D Huang, W Shang, M Xu, Q Wan, J Zhang… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: Despite advances in understanding hypertension's genetic structure, how
noncoding genetic variants influence it remains unclear. Studying their interaction with DNA …
noncoding genetic variants influence it remains unclear. Studying their interaction with DNA …
[HTML][HTML] Semimethylation is a feature of diffuse large B-cell lymphoma, and subgroups with poor prognosis are characterized by global hypomethylation and short …
O Carlund, E Thörn, P Osterman, M Fors, A Dernstedt… - Clinical …, 2024 - Springer
Background Large B-cell lymphoma (LBCL) is the most common lymphoma and is known to
be a biologically heterogeneous disease regarding genetic, phenotypic, and clinical …
be a biologically heterogeneous disease regarding genetic, phenotypic, and clinical …
Investigating the potential of single-cell DNA methylation data to detect allele-specific methylation and imprinting
Allele-specific methylation (ASM) is an epigenetic modification whereby one parental allele
becomes methylated and the other unmethylated at a specific locus. ASM is most often …
becomes methylated and the other unmethylated at a specific locus. ASM is most often …
[HTML][HTML] Sex-dependent placental methylation quantitative trait loci provide insight into the prenatal origins of childhood onset traits and conditions
Molecular quantitative trait loci (QTLs) allow us to understand the biology captured in
genome-wide association studies (GWASs). The placenta regulates fetal development and …
genome-wide association studies (GWASs). The placenta regulates fetal development and …
[HTML][HTML] Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse …
Hepatic xenobiotic metabolism and transport decline with age, while intact xenobiotic
metabolism is associated with longevity. However, few studies have examined the genome …
metabolism is associated with longevity. However, few studies have examined the genome …
Investigating the relationship between DNA methylation, genetic variation, and suicide attempt in bipolar disorder
Individuals with bipolar disorder are at increased risk for suicide, and this can be influenced
by a range of biological, clinical, and environmental risk factors. Biological components …
by a range of biological, clinical, and environmental risk factors. Biological components …
A hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data
Background: Methylation Quantitative Trait Loci (meQTLs) are chromosomal regions that
harbor genetic variants affecting DNA methylation levels. The identification of meQTLs can …
harbor genetic variants affecting DNA methylation levels. The identification of meQTLs can …