Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer
D Oluwalana, KL Adeleye, RI Krutilina, H Chen… - Cancer Letters, 2024 - Elsevier
Background Improving survival for patients diagnosed with metastatic disease and
overcoming chemoresistance remain significant clinical challenges in treating breast cancer …
overcoming chemoresistance remain significant clinical challenges in treating breast cancer …
Discovery of Novel Diaryl-Substituted Fused Heterocycles Targeting Katanin and Tubulin with Potent Antitumor and Antimultidrug Resistance Efficacy
F Jiang, M Yu, Y Liang, K Ding… - Journal of Medicinal …, 2024 - ACS Publications
Disrupting microtubule dynamics has emerged as a promising strategy for cancer treatment.
However, drug resistance remains a challenge hindering the development of microtubule …
However, drug resistance remains a challenge hindering the development of microtubule …
Novel Antimitotic Agent SP-1-39 Inhibits Head and Neck Squamous Cell Carcinoma
Effective management of head and neck cancer (HNC) poses a significant challenge in the
field of oncology, due to its intricate pathophysiology and limited treatment options. The most …
field of oncology, due to its intricate pathophysiology and limited treatment options. The most …
Overcoming resistance in prostate cancer with targeted and small molecule-based therapies
S Gogola, M Rejzer, R Poppiti - Therapy Resistance in Prostate Cancer, 2024 - Elsevier
Targeted therapies for cancer treatment utilize a range of small-molecule drugs or
monoclonal antibodies to influence cancer cell growth, survival, and spread. For prostate …
monoclonal antibodies to influence cancer cell growth, survival, and spread. For prostate …