Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization
The synthesis and evaluation of small-molecule inhibitors of tubulin polymerization remains
a promising approach for the development of new therapeutic agents for cancer treatment …
a promising approach for the development of new therapeutic agents for cancer treatment …
Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer
D Oluwalana, KL Adeleye, RI Krutilina, H Chen… - Cancer Letters, 2024 - Elsevier
Background Improving survival for patients diagnosed with metastatic disease and
overcoming chemoresistance remain significant clinical challenges in treating breast cancer …
overcoming chemoresistance remain significant clinical challenges in treating breast cancer …
Design, synthesis and biological evaluation of 1, 2, 3-triazole benzothiazole derivatives as tubulin polymerization inhibitors with potent anti-esophageal cancer …
BW Wu, WJ Huang, YH Liu, QG Liu, J Song… - European Journal of …, 2024 - Elsevier
In this work, we utilized the molecular hybridization strategy to design and synthesize novel
1, 2, 3-triazole benzothiazole derivatives K1-26. The antiproliferative activities against MGC …
1, 2, 3-triazole benzothiazole derivatives K1-26. The antiproliferative activities against MGC …
Structure-activity relationship study of new carbazole sulfonamide derivatives as anticancer agents with dual-target mechanism
Y Liu, J Zhang, J Tian, C Wang, T Wang, J Gong… - European Journal of …, 2024 - Elsevier
A series of novel carbazole sulfonamide derivatives were synthesized and evaluated for
antiproliferative activity. Among them, compounds 7 and 15 showed strong potency (IC 50 …
antiproliferative activity. Among them, compounds 7 and 15 showed strong potency (IC 50 …
Modular preparation of biphenyl triazoles via click chemistry as non-competitive hyaluronidase inhibitors
Y Qin, G Li, L Wang, G Yin, X Zhang, H Wang… - Bioorganic …, 2024 - Elsevier
Hyaluronidase is a promising target in drug discovery, given its overexpression in a range of
physiological and pathological processes, including tumor migration, skin aging, sagging …
physiological and pathological processes, including tumor migration, skin aging, sagging …