New biomarkers in acute kidney injury

A Rossiter, A La, JL Koyner, LG Forni - Critical Reviews in Clinical …, 2024 - Taylor & Francis
Acute kidney injury (AKI) is a commonly encountered clinical syndrome. Although it often
complicates community acquired illness, it is more common in hospitalized patients …

Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) as a Prognostic Biomarker in Acute Kidney Injury: A Narrative Review

C Delrue, MM Speeckaert - Diagnostics, 2024 - mdpi.com
Acute kidney damage (AKI) is a serious and common consequence among critically unwell
individuals. Traditional biomarkers, such as serum creatinine, frequently fail to detect AKI in …

Urinary TIMP-2* IGFBP-7 to diagnose acute kidney injury in children receiving cisplatin

H Chui, KR McMahon, SR Rassekh, KR Schultz… - Pediatric …, 2024 - Springer
Background Cisplatin is associated with acute kidney injury (AKI) and electrolyte
abnormalities. Urine tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth …

Urinary beta-2 microglobulin increases whereas TIMP-2 and IGFBP7 decline after unilateral nephrectomy in healthy kidney donors

ENM de Rooij, EK Hoogeveen, FP Romijn… - Scientific Reports, 2024 - nature.com
Early kidney injury may be detected by urinary markers, such as beta-2 microglobulin (B2M),
tissue inhibitor of metalloproteinases-2 (TIMP-2), insulin-like growth factor-binding protein 7 …

TIMP2 protects against sepsis-associated acute kidney injury by cAMP/NLRP3 axis-mediated pyroptosis

D Xu, J Jiang, Y Liu, J Pang, J Suo… - American Journal of …, 2024 - journals.physiology.org
The tissue inhibitor of metalloproteinases 2 (TIMP2) has emerged as a promising biomarker
for predicting the risk of sepsis-associated acute kidney injury (SA-AKI). However, its exact …

Discovery and verification of mmu_Circ_26986/hsa_Circ_0072463 as a potential biomarker and intervention target for sepsis-associated acute kidney injury

X Peng, H Li, W Zhang, D Zhang - Cellular and Molecular Life Sciences, 2024 - Springer
Approximately 60% of septic patients developed acute kidney injury (AKI). The mortality rate
of septic AKI (SA-AKI) is two to three times higher than that of septic without AKI (SA-non …

Benzylic rearrangement for urinary analysis of guanidino and ureido compounds in cardiac surgery–associated acute kidney injury using high‐performance liquid …

Y Bai, Y Zou, Y Zeng, L Hu, S Huang… - Rapid …, 2024 - Wiley Online Library
Rationale Because acute kidney injury (AKI) is closely related to poor prognosis in critically
ill patients, developing biomarkers for its prediction and early diagnosis is particularly …

[HTML][HTML] Continuous urine output-based alert identifies cardiac surgery-associated acute kidney injury earlier than serum creatinine-a prospective and retrospective …

V Moll, M Zhao, S Minear, M Swaminathan… - … of Cardiothoracic and …, 2024 - Elsevier
Objective (s) Acute kidney injury (AKI) is defined and staged by reduced urine output (UO)
and increased serum creatinine (SCr). UO is typically measured manually and documented …

[HTML][HTML] Statistical analysis plan for the biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2) study: An international randomised …

T von Groote, MF Danzer, M Meersch, A Zarbock… - Critical Care and …, 2024 - Elsevier
Objective This article describes the statistical analysis plan for the Biomarker-guided
intervention to prevent AKI after major surgery (BigpAK-2) trial. Design Adaptive trial design …

Diagnostic and Prognostic Values of KLF5 and RUNX1 in Acute Kidney Injury in Septic Patients

JJ Hu, YS Lin, YH Wang, YF Shi, XH Shi… - Applied Biochemistry and …, 2024 - Springer
Diagnostic and prognostic values of Kruppel-like factor 5 (KLF5) and Runt-related
transcription factor 1 (RUNX1) were determined in sepsis-induced acute kidney injury (SI …