ScreenDMT reveals DiHOMEs are replicably inversely associated with BMI and stimulate adipocyte calcium influx

JM Dreyfuss, V Djordjilović, H Pan, V Bussberg… - Communications …, 2024 - nature.com
Activating brown adipose tissue (BAT) improves systemic metabolism, making it a promising
target for metabolic syndrome. BAT is activated by 12, 13-dihydroxy-9Z-octadecenoic acid …

Detecting responsible nodes in differential Bayesian networks

X Huang, H Zhang - Statistics in Medicine, 2024 - Wiley Online Library
To study the roles that different nodes play in differentiating Bayesian networks under two
states, such as control versus disease, we formulate two node‐specific scores to facilitate …

Global Interactome Mapping Reveals Pro-tumorigenic Interactions of NF-κB in Breast Cancer

P Lapcik, RG Stacey, D Potesil, P Kulhanek… - Molecular & Cellular …, 2024 - ASBMB
NF-κB pathway is involved in inflammation; however, recent data shows its role also in
cancer development and progression, including metastasis. To understand the role of NF-κB …

Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient

A Fiebig, MK Schnizlein, S Pena-Rivera, F Trigodet… - Mbio, 2024 - Am Soc Microbiol
ABSTRACT Bacteroides fragilis comprises 1%–5% of the gut microbiota in healthy humans
but can expand to> 50% of the population in ulcerative colitis (UC) patients experiencing …

[HTML][HTML] Transcriptomic Module Discovery of Diarrhea-Predominant Irritable Bowel Syndrome: A Causal Network Inference Approach

D Guido, F Maqoud, M Aloisio, D Mallardi… - International Journal of …, 2024 - mdpi.com
Irritable bowel syndrome with diarrhea (IBS-D) is the most prevalent subtype of IBS,
characterized by chronic gastrointestinal symptoms in the absence of identifiable …

Biological network comparison identifies a novel synergistic mechanism of Ginseng Radix-Astragali Radix herb pair in cancer-related fatigue.

MN Tran, NS Kim, S Lee - Journal of Ethnopharmacology, 2024 - Elsevier
Abstract Ethnopharmacological relevance Ginseng Radix and Astragali Radix are
commonly combined to tonify Qi and alleviate fatigue. Previous studies have employed …

A method for mining condition-specific co-expressed genes in Camellia sinensis based on k-means clustering

X Zheng, PK Lim, M Mutwil, Y Wang - BMC Plant Biology, 2024 - Springer
Background As one of the world's most important beverage crops, tea plants (Camellia
sinensis) are renowned for their unique flavors and numerous beneficial secondary …

Network biology approach unveils transcriptomic alterations triggered by particle radiation

ZP Liu, T Wang - Molecular Therapy-Nucleic Acids, 2024 - cell.com
Spaceflight imposes unique environmental stresses to organisms, radiation exposure being
a prominent one, which holds the potential to exert detrimental impacts on biological …

Statistical inference on qualitative differences in the magnitude of an effect

A Hudson, A Shojaie - Statistics in Medicine, 2024 - Wiley Online Library
Qualitative interactions occur when a treatment effect or measure of association varies in
sign by sub‐population. Of particular interest in many biomedical settings are …

Inference of differential gene regulatory networks using boosted differential trees

G Galindez, M List, J Baumbach, U Völker… - Bioinformatics …, 2024 - academic.oup.com
Diseases can be caused by molecular perturbations that induce specific changes in
regulatory interactions and their coordinated expression, also referred to as network …