Obesity in children remains a major public health problem, with the current prevalence in
youth ages 2–19 years estimated to be 19.7%. Despite progress in identifying risk factors …

Obesity is a major risk factor for a myriad of diseases, affecting> 600 million people
worldwide. Genome-wide association studies (GWASs) have identified hundreds of genetic …

Cell-type-specific regulatory elements, cataloged through extensive experiments and
bioinformatics in large-scale consortiums, have enabled enrichment analyses of genetic …

Polygenic risk scores (PRSs) are now showing promising predictive performance on a wide
variety of complex traits and diseases, but there exists a substantial performance gap across …

The purpose of this work was to find a link between the breast cancer (BC)-risk effects of sex
hormone-binding globulin (SHBG)-associated polymorphisms and obesity. The study was …

The investigation of environmental effects on clinical measurements using individual
samples is challenging because their genetic and environmental factors are different …

Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes, and molecular mechanisms that are often specific to cell …

Major depression (MD) and obesity are complex genetic disorders that are frequently
comorbid. However, the study of both diseases concurrently remains poorly addressed and …

Background Sympathetic activation of brown adipose tissue (BAT) thermogenesis can
ameliorate obesity and related metabolic abnormalities. However, crucial subtypes of the β …

Despite the high prevalence of snoring in Asia, little is known about the genetic etiology of
snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese …