Immunological roads diverged: mapping tuberculosis outcomes in mice
RK Meade, CM Smith - Trends in Microbiology, 2024 - cell.com
The journey from phenotypic observation to causal genetic mechanism is a long and
challenging road. For pathogens like Mycobacterium tuberculosis (Mtb), which causes …
challenging road. For pathogens like Mycobacterium tuberculosis (Mtb), which causes …
Neutrophil‐plasmacytoid dendritic cell interaction leads to production of type I IFN in response to Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) can cause a latent infection that sometimes progresses to
clinically active tuberculosis (TB). Type I interferons (IFN‐I) have been implicated in initiating …
clinically active tuberculosis (TB). Type I interferons (IFN‐I) have been implicated in initiating …
Type I interferon exacerbates Mycobacterium tuberculosis induced human macrophage death
AM Lee, CF Nathan - EMBO reports, 2024 - embopress.org
Abstract Type I interferons (IFN-I) are implicated in exacerbation of tuberculosis (TB), but the
mechanisms are unclear. Mouse macrophages infected with Mycobacterium tuberculosis …
mechanisms are unclear. Mouse macrophages infected with Mycobacterium tuberculosis …
Human alveolar and monocyte-derived human macrophage responses to Mycobacterium tuberculosis
M Campo, KA Dill-McFarland, GJ Peterson… - The Journal of …, 2024 - journals.aai.org
Alveolar macrophages (AMs) and recruited monocyte-derived macrophages (MDMs)
mediate early lung immune responses to Mycobacterium tuberculosis. Differences in the …
mediate early lung immune responses to Mycobacterium tuberculosis. Differences in the …
Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway
Y Ding, J Tong, G Luo, R Sun, C Bei, Z Feng, L Meng… - Iscience, 2024 - cell.com
Type I interferon (IFN) production is crucial in tuberculosis pathogenesis, yet the bacterial
factors initiating this process are incompletely understood. CpsA, protein of Mycobacterium …
factors initiating this process are incompletely understood. CpsA, protein of Mycobacterium …
[HTML][HTML] Demonstrating the utility of the ex vivo murine mycobacterial growth inhibition assay (MGIA) for high-throughput screening of tuberculosis vaccine candidates …
Human tuberculosis (TB) is caused by various members of the Mycobacterium tuberculosis
(Mtb) complex. Differences in host response to infection have been reported, illustrative of a …
(Mtb) complex. Differences in host response to infection have been reported, illustrative of a …