Exploring and analyzing the systemic delivery barriers for nanoparticles

L Wang, S Quine, AN Frickenstein… - Advanced Functional …, 2024 - Wiley Online Library
Most nanomedicines require efficient in vivo delivery to elicit meaningful diagnostic and
therapeutic effects. However, en route to their intended tissues, systemically administered …

Harnessing anti-inflammatory pathways and macrophage nano delivery to treat inflammatory and fibrotic disorders

A Zaid, A Ariel - Advanced Drug Delivery Reviews, 2024 - Elsevier
Targeting specific organs and cell types using nanotechnology and sophisticated delivery
methods has been at the forefront of applicative biomedical sciences lately. Macrophages …

Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation–induced surfactant secretion

GL Chen, JY Li, X Chen, JW Liu… - The Journal of …, 2024 - Am Soc Clin Investig
Pulmonary surfactant is a lipoprotein complex lining the alveolar surface to decrease the
surface tension and facilitate inspiration. Surfactant deficiency is often seen in premature …

Iterative nanoparticle bioengineering enabled by x-ray fluorescence imaging

GM Saladino, B Brodin, R Kakadiya, MS Toprak… - Science …, 2024 - science.org
Nanoparticles (NPs) are currently developed for drug delivery and molecular imaging.
However, they often get intercepted before reaching their target, leading to low targeting …

Three-dimensional imaging studies in mice identify cellular dynamics of skeletal muscle regeneration

BC Collins, JB Shapiro, MM Scheib, RV Musci… - Developmental Cell, 2024 - cell.com
The function of many organs, including skeletal muscle, depends on their three-dimensional
structure. Muscle regeneration therefore requires not only reestablishment of myofibers but …

Ligand‐selective targeting of macrophage hydrogel elicits bone immune‐stem cell endogenous self‐healing program to promote bone regeneration

J Wang, L Zhang, L Wang, J Tang… - Advanced …, 2024 - Wiley Online Library
Targeting macrophages can facilitate the site‐specific repair of critical bone defects. Herein,
a composite hydrogel, gelatin‐Bletilla striata polysaccharide‐mesoporous bioactive glass …

Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells

L Zhang, H Saito, T Higashimoto, T Kaji, A Nakamura… - Cell reports, 2024 - cell.com
Skeletal muscles exert remarkable regenerative or adaptive capacities in response to
injuries or mechanical loads. However, the cellular networks underlying muscle adaptation …

Unraveling the complex roles of macrophages in obese adipose tissue: an overview

C Peng, J Chen, R Wu, H Jiang, J Li - Frontiers of medicine, 2024 - Springer
Macrophages, a heterogeneous population of innate immune cells, exhibit remarkable
plasticity and play pivotal roles in coordinating immune responses and maintaining tissue …

Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site

N Abbas, K You, A Getachew, F Wu, M Hussain… - Stem Cell Research & …, 2024 - Springer
Background Allogeneic hepatocyte transplantation is an emerging approach to treat acute
liver defects. However, durable engraftment of the transplanted cells remains a daunting …

Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery

IV Zelepukin, KG Shevchenko, SM Deyev - Nature Communications, 2024 - nature.com
Rapid uptake of nanoparticles by mononuclear phagocyte system (MPS) significantly
hampers their therapeutic efficacy. Temporal MPS blockade is one of the few ways to …