Cardiometabolic diseases include metabolic syndrome, obesity, type 2 diabetes mellitus,
and hypertension. Epigenetic modifications participate in cardiometabolic diseases through …

Abstract Purpose of Review Osteoarthritis is a complex and highly polygenic disease. Over
100 reported osteoarthritis risk variants fall in non-coding regions of the genome, ostensibly …

We present a systematic analysis of epigenetic age acceleration based on by far the largest
collection of publicly available DNA methylation data for healthy samples (93 datasets, 23 K …

Background: Evidence suggests that prenatal air pollution exposure alters DNA methylation
(DNAm), which could go on to affect long-term health. It remains unclear whether DNAm …

To control genetic background and early life milieu in genome-wide DNA methylation
analysis for blood lipids, we recruited Chinese discordant monozygotic twins to explore the …

Over 50% of children with a parent with severe mental illness will develop mental illness by
early adulthood. However, intergenerational transmission of risk for mental illness in one's …

Clonal hematopoiesis becomes increasingly common with age, but its cause is enigmatic
because driver mutations are often absent. Serial observations infer weak selection …

This study was designed to examine the effect of resveratrol on mitochondrial biogenesis,
oxidative stress (OS), and assisted reproductive technology (ART) outcomes in individuals …

Many organisms can adjust their development according to environmental conditions,
including the presence of conspecifics. Although this developmental plasticity is common in …

Introduction Little is known about the interplay between genetics and epigenetics on
antidepressant treatment (1) response and remission,(2) side effects, and (3) serum levels …